BDBM50414963 CHEMBL583212

SMILES: FC(F)C(F)(F)Oc1ccccc1CN1CCC2(CC1)CCN(CC2)C(=O)c1ccncc1

InChI Key: InChIKey=ZQYTURKIACTXPU-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50414963   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Potassium voltage-gated channel subfamily H member 2 (Homo sapiens (Human))	BDBM50414963 (CHEMBL583212) Show SMILES FC(F)C(F)(F)Oc1ccccc1CN1CCC2(CC1)CCN(CC2)C(=O)c1ccncc1 Show InChI InChI=1S/C24H27F4N3O2/c25-22(26)24(27,28)33-20-4-2-1-3-19(20)17-30-13-7-23(8-14-30)9-15-31(16-10-23)21(32)18-5-11-29-12-6-18/h1-6,11-12,22H,7-10,13-17H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.70E+4	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Displacement of [3H]dofetilide from human recombinant ERG expressed in HEK293 cells by patch clamp method				J Med Chem 52: 7706-23 (2009) Article DOI: 10.1021/jm900713y BindingDB Entry DOI: 10.7270/Q2TH8NZP
					More data for this Ligand-Target Pair
C-C chemokine receptor type 8 (Homo sapiens (Human))	BDBM50414963 (CHEMBL583212) Show SMILES FC(F)C(F)(F)Oc1ccccc1CN1CCC2(CC1)CCN(CC2)C(=O)c1ccncc1 Show InChI InChI=1S/C24H27F4N3O2/c25-22(26)24(27,28)33-20-4-2-1-3-19(20)17-30-13-7-23(8-14-30)9-15-31(16-10-23)21(32)18-5-11-29-12-6-18/h1-6,11-12,22H,7-10,13-17H2	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	525	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Antagonist activity at human CCR8				J Med Chem 52: 7706-23 (2009) Article DOI: 10.1021/jm900713y BindingDB Entry DOI: 10.7270/Q2TH8NZP
					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2 (Homo sapiens (Human))	BDBM50414963 (CHEMBL583212) Show SMILES FC(F)C(F)(F)Oc1ccccc1CN1CCC2(CC1)CCN(CC2)C(=O)c1ccncc1 Show InChI InChI=1S/C24H27F4N3O2/c25-22(26)24(27,28)33-20-4-2-1-3-19(20)17-30-13-7-23(8-14-30)9-15-31(16-10-23)21(32)18-5-11-29-12-6-18/h1-6,11-12,22H,7-10,13-17H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	5.13E+3	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Inhibition of wild type human ERG expressed in CHOK1 cells by whole-cell plate-based electrophysiology				J Med Chem 52: 7706-23 (2009) Article DOI: 10.1021/jm900713y BindingDB Entry DOI: 10.7270/Q2TH8NZP
					More data for this Ligand-Target Pair