Found 4 hits for monomerid = 50414965 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kcal/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
C-C chemokine receptor type 8
(Homo sapiens (Human)) | BDBM50414965
(CHEMBL270971)Show SMILES COc1ccccc1Oc1ccccc1CN1CCC2(CC1)CCN(CC2)C(=O)c1cc[n+]([O-])cc1 Show InChI InChI=1S/C29H33N3O4/c1-35-26-8-4-5-9-27(26)36-25-7-3-2-6-24(25)22-30-18-12-29(13-19-30)14-20-31(21-15-29)28(33)23-10-16-32(34)17-11-23/h2-11,16-17H,12-15,18-22H2,1H3 | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 115 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Antagonist activity at CCR8 receptor |
J Med Chem 51: 1162-78 (2008)
Article DOI: 10.1021/jm070543k
BindingDB Entry DOI: 10.7270/Q2C24XMG |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human)) | BDBM50414965
(CHEMBL270971)Show SMILES COc1ccccc1Oc1ccccc1CN1CCC2(CC1)CCN(CC2)C(=O)c1cc[n+]([O-])cc1 Show InChI InChI=1S/C29H33N3O4/c1-35-26-8-4-5-9-27(26)36-25-7-3-2-6-24(25)22-30-18-12-29(13-19-30)14-20-31(21-15-29)28(33)23-10-16-32(34)17-11-23/h2-11,16-17H,12-15,18-22H2,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
UniProtKB/TrEMBL
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 219 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of wild type human ERG expressed in CHOK1 cells by whole-cell plate-based electrophysiology |
J Med Chem 52: 7706-23 (2009)
Article DOI: 10.1021/jm900713y
BindingDB Entry DOI: 10.7270/Q2TH8NZP |
More data for this
Ligand-Target Pair | |
C-C chemokine receptor type 8
(Homo sapiens (Human)) | BDBM50414965
(CHEMBL270971)Show SMILES COc1ccccc1Oc1ccccc1CN1CCC2(CC1)CCN(CC2)C(=O)c1cc[n+]([O-])cc1 Show InChI InChI=1S/C29H33N3O4/c1-35-26-8-4-5-9-27(26)36-25-7-3-2-6-24(25)22-30-18-12-29(13-19-30)14-20-31(21-15-29)28(33)23-10-16-32(34)17-11-23/h2-11,16-17H,12-15,18-22H2,1H3 | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 115 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Antagonist activity at human CCR8 |
J Med Chem 52: 7706-23 (2009)
Article DOI: 10.1021/jm900713y
BindingDB Entry DOI: 10.7270/Q2TH8NZP |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human)) | BDBM50414965
(CHEMBL270971)Show SMILES COc1ccccc1Oc1ccccc1CN1CCC2(CC1)CCN(CC2)C(=O)c1cc[n+]([O-])cc1 Show InChI InChI=1S/C29H33N3O4/c1-35-26-8-4-5-9-27(26)36-25-7-3-2-6-24(25)22-30-18-12-29(13-19-30)14-20-31(21-15-29)28(33)23-10-16-32(34)17-11-23/h2-11,16-17H,12-15,18-22H2,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
UniProtKB/TrEMBL
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 209 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Displacement of [3H]dofetilide from human recombinant ERG expressed in HEK293 cells by patch clamp method |
J Med Chem 52: 7706-23 (2009)
Article DOI: 10.1021/jm900713y
BindingDB Entry DOI: 10.7270/Q2TH8NZP |
More data for this
Ligand-Target Pair | |
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