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SMILES: CC[C@@]1(O)C(=O)OCc2c1cc1-c3nc4ccc(cc4cc3Cn1c2=O)C#N

InChI Key: InChIKey=AVTDTIXTCDVJBC-NRFANRHFSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50422004   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
DNA topoisomerase 1


(Homo sapiens (Human))		BDBM50422004
PNG
(CHEMBL10724)
Show SMILES CC[C@@]1(O)C(=O)OCc2c1cc1-c3nc4ccc(cc4cc3Cn1c2=O)C#N
Show InChI InChI=1S/C21H15N3O4/c1-2-21(27)15-7-17-18-13(6-12-5-11(8-22)3-4-16(12)23-18)9-24(17)19(25)14(15)10-28-20(21)26/h3-7,27H,2,9-10H2,1H3/t21-/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/a 1.90E+3n/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Inhibition of Topoisomerase I by cleavage complex formation in human HL-60 cells

J Med Chem 36: 2689-700 (1993)


BindingDB Entry DOI: 10.7270/Q2KP82RH
More data for this
Ligand-Target Pair