BDBM50423945 CHEMBL2313399

SMILES: CN(C)c1ccccc1CNC(=O)c1sc2nc(C)c(Cl)c(C)c2c1N

InChI Key: InChIKey=DXJGMJHFQFOCEG-UHFFFAOYSA-N

Data: 1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50423945   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Muscarinic acetylcholine receptor M4 (Homo sapiens (Human))	BDBM50423945 (CHEMBL2313399) Show SMILES CN(C)c1ccccc1CNC(=O)c1sc2nc(C)c(Cl)c(C)c2c1N Show InChI InChI=1S/C19H21ClN4OS/c1-10-14-16(21)17(26-19(14)23-11(2)15(10)20)18(25)22-9-12-7-5-6-8-13(12)24(3)4/h5-8H,9,21H2,1-4H3,(H,22,25)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Positive allosteric modulation of human muscarinic M4 receptor expressed in CHO-K1 cells assessed as leftward shift in acetylcholine response treated...				Bioorg Med Chem Lett 23: 346-50 (2012) Article DOI: 10.1016/j.bmcl.2012.10.073 BindingDB Entry DOI: 10.7270/Q2N29Z8S
					More data for this Ligand-Target Pair