BDBM50423950 CHEMBL2313394

SMILES: Cc1nc2sc(C(=O)NCc3ccccc3Cl)c(N)c2c(C)c1Cl

InChI Key: InChIKey=UMIVFEPGKJAAJG-UHFFFAOYSA-N

Data: 1 EC50

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50423950   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Muscarinic acetylcholine receptor M4 (Homo sapiens (Human))	BDBM50423950 (CHEMBL2313394) Show SMILES Cc1nc2sc(C(=O)NCc3ccccc3Cl)c(N)c2c(C)c1Cl Show InChI InChI=1S/C17H15Cl2N3OS/c1-8-12-14(20)15(24-17(12)22-9(2)13(8)19)16(23)21-7-10-5-3-4-6-11(10)18/h3-6H,7,20H2,1-2H3,(H,21,23)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	160	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Positive allosteric modulation of human muscarinic M4 receptor expressed in CHO-K1 cells assessed as leftward shift in acetylcholine response treated...				Bioorg Med Chem Lett 23: 346-50 (2012) Article DOI: 10.1016/j.bmcl.2012.10.073 BindingDB Entry DOI: 10.7270/Q2N29Z8S
					More data for this Ligand-Target Pair