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SMILES: Cc1nc2sc(C(=O)NCc3cccc(F)c3F)c(N)c2c(C)c1Cl

InChI Key: InChIKey=ZLQJRRFMFACGIH-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50423969   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Muscarinic acetylcholine receptor M4


(Homo sapiens (Human))		BDBM50423969
PNG
(CHEMBL2313376)
Show SMILES Cc1nc2sc(C(=O)NCc3cccc(F)c3F)c(N)c2c(C)c1Cl
Show InChI InChI=1S/C17H14ClF2N3OS/c1-7-11-14(21)15(25-17(11)23-8(2)12(7)18)16(24)22-6-9-4-3-5-10(19)13(9)20/h3-5H,6,21H2,1-2H3,(H,22,24)
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Article
PubMed
n/an/an/an/a 124n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human muscarinic M4 receptor expressed in CHO-K1 cells assessed as leftward shift in acetylcholine response treated...

Bioorg Med Chem Lett 23: 346-50 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.073
BindingDB Entry DOI: 10.7270/Q2N29Z8S
More data for this
Ligand-Target Pair