BDBM50425058 CHEMBL2312902

SMILES: O=C1c2ccccc2-c2c1c1ccc(cc1c(=O)n2CCCn1ccnc1)C#N

InChI Key: InChIKey=SCKRHNGUSKPPKU-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50425058   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosyl-DNA phosphodiesterase 1 (TDP1) (Homo sapiens (Human))	BDBM50425058 (CHEMBL2312902) Show SMILES O=C1c2ccccc2-c2c1c1ccc(cc1c(=O)n2CCCn1ccnc1)C#N Show InChI InChI=1S/C23H16N4O2/c24-13-15-6-7-16-19(12-15)23(29)27(10-3-9-26-11-8-25-14-26)21-17-4-1-2-5-18(17)22(28)20(16)21/h1-2,4-8,11-12,14H,3,9-10H2	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.11E+5	n/a	n/a	n/a	n/a	n/a	n/a
Purdue University Curated by ChEMBL					Assay Description Inhibition of recombinant Tdp1 (unknown origin) using 5'-[32P]-labeled single-stranded DNA oligonucleotide containing 3'-phosphotyrosine as substrate...				J Med Chem 56: 182-200 (2013) Article DOI: 10.1021/jm3014458 BindingDB Entry DOI: 10.7270/Q2MS3V3Z
					More data for this Ligand-Target Pair