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SMILES: Cc1cc(C)c(c(C)c1)S(=O)(=O)c1ccc(OC2CCN(CC2)C(=O)OC(C)(C)C)cc1

InChI Key: InChIKey=JCTYYKHIPVELDQ-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50425546   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Rap guanine nucleotide exchange factor 4


(Homo sapiens (Human))		BDBM50425546
PNG
(CHEMBL2313662)
Show SMILES Cc1cc(C)c(c(C)c1)S(=O)(=O)c1ccc(OC2CCN(CC2)C(=O)OC(C)(C)C)cc1
Show InChI InChI=1S/C25H33NO5S/c1-17-15-18(2)23(19(3)16-17)32(28,29)22-9-7-20(8-10-22)30-21-11-13-26(14-12-21)24(27)31-25(4,5)6/h7-10,15-16,21H,11-14H2,1-6H3
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n/an/a>3.00E+5n/an/an/an/an/an/a



University of Texas Medical Branch

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant EPAC2 (unknown origin) assessed 8-NBD-cAMP substrate fluorescence intensity by substrate competing assay

J Med Chem 56: 952-62 (2013)


Article DOI: 10.1021/jm3014162
BindingDB Entry DOI: 10.7270/Q2D21ZX3
More data for this
Ligand-Target Pair