BDBM50426077 CHEMBL2315999
SMILES: CC[C@H](C)[C@H](OCc1ccccc1)[C@H]1[C@@H]([C@@H](N[C@]1(C)C(=O)NCCC(O)=O)c1ccccc1)[N+]([O-])=O
InChI Key: InChIKey=WSUFYWDDGAKRPT-NVQOMKKLSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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Integrin alpha-L/beta-2 (LFA-1) (Homo sapiens (Human)) | BDBM50426077 (CHEMBL2315999) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | 1.01E+4 | n/a | n/a | n/a | n/a | n/a |
Ikerchem Ltd. Curated by ChEMBL | Assay Description Binding affinity to I-domain of human integrin alphaL (amino acid residues 128 to 307) plus initial methionine expressed in Escherichia coli by NMR s... | J Med Chem 56: 735-47 (2013) Article DOI: 10.1021/jm3016848 BindingDB Entry DOI: 10.7270/Q2862HSF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
integrin alpha-L (Mus musculus) | BDBM50426077 (CHEMBL2315999) | UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2.76E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Ikerchem Ltd. Curated by ChEMBL | Assay Description Inhibition of LFA-1/ICAM-1 interaction in mouse Lim51b cells assessed as PMA-induced adhesion to ICAM-1 expressing HSE cells measured per 10'5 cells ... | J Med Chem 56: 735-47 (2013) Article DOI: 10.1021/jm3016848 BindingDB Entry DOI: 10.7270/Q2862HSF | |||||||||||
More data for this Ligand-Target Pair |