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SMILES: CC(=NNC(N)=S)[C@]1(C)C[C@]2(CC(C)(C)OC2=O)C(=O)O1

InChI Key: InChIKey=YQINBAFGCQXUBM-STQMWFEESA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50426143   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Cathepsin K


(Homo sapiens (Human))		BDBM50426143
PNG
(CHEMBL2316598)
Show SMILES CC(=NNC(N)=S)[C@]1(C)C[C@]2(CC(C)(C)OC2=O)C(=O)O1 |r,w:2.2|
Show InChI InChI=1S/C13H19N3O4S/c1-7(15-16-10(14)21)12(4)6-13(9(18)20-12)5-11(2,3)19-8(13)17/h5-6H2,1-4H3,(H3,14,16,21)/t12-,13-/m0/s1
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n/an/a 5.80E+3n/an/an/an/an/an/a



MSD Animal Health Innovation GmbH

Curated by ChEMBL


Assay Description
Inhibition of human recombinant His-tagged cathepsin K using Cbz-Phe-Arg-AMC as substrate incubated for 30 mins prior to substrate addition by FRET a...

J Med Chem 56: 1478-90 (2013)


Article DOI: 10.1021/jm3013932
BindingDB Entry DOI: 10.7270/Q2W09774
More data for this
Ligand-Target Pair