BDBM50426803 CHEMBL2322772

SMILES: CN(C(=O)c1cc2CCOc3cccnc3-c2s1)c1ccccc1Cl

InChI Key: InChIKey=FWNWKYWPHOIMQC-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50426803   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM50426803 (CHEMBL2322772) Show SMILES CN(C(=O)c1cc2CCOc3cccnc3-c2s1)c1ccccc1Cl Show InChI InChI=1S/C19H15ClN2O2S/c1-22(14-6-3-2-5-13(14)20)19(23)16-11-12-8-10-24-15-7-4-9-21-17(15)18(12)25-16/h2-7,9,11H,8,10H2,1H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc. Curated by ChEMBL					Assay Description Inhibition of PI3Kalpha-mediated AKT Ser 473 phosphorylation in human PC3 cells				Bioorg Med Chem Lett 23: 897-901 (2013) Article DOI: 10.1016/j.bmcl.2012.10.121 BindingDB Entry DOI: 10.7270/Q21C1Z5X
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM50426803 (CHEMBL2322772) Show SMILES CN(C(=O)c1cc2CCOc3cccnc3-c2s1)c1ccccc1Cl Show InChI InChI=1S/C19H15ClN2O2S/c1-22(14-6-3-2-5-13(14)20)19(23)16-11-12-8-10-24-15-7-4-9-21-17(15)18(12)25-16/h2-7,9,11H,8,10H2,1H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc. Curated by ChEMBL					Assay Description Inhibition of recombinant PI3Kalpha (unknown origin)-mediated 3,4,5-inositoltriphosphate formation after 30 mins by TAMRA-PIP3-based competitive fluo...				Bioorg Med Chem Lett 23: 897-901 (2013) Article DOI: 10.1016/j.bmcl.2012.10.121 BindingDB Entry DOI: 10.7270/Q21C1Z5X
					More data for this Ligand-Target Pair