BDBM50427457 CHEMBL2326952::US10308662, Compound 25::US9505780, 25
SMILES: CCOC(=O)c1ccc(cc1)-c1csc2c1oc(cc2=O)N1CCOCC1
InChI Key: InChIKey=VRBZWFAUTHKRBB-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Bromodomain-containing protein 4 Bromo 1 domain(BRD4 BD1) (Homo sapiens (Human)) | BDBM50427457 (CHEMBL2326952 | US10308662, Compound 25 | US950578...) | GoogleScholar AffyNet | CHEMBL PC cid PC sid PDB UniChem Similars | US Patent | n/a | n/a | 277 | n/a | n/a | n/a | n/a | n/a | n/a |
SignalRx Pharmaceuticals, Inc. US Patent | Assay Description Several TP Scaffold compounds were tested for inhibition activity against isoforms of PI3K (alpha, beta, gamma, and delta isoforms) and the bromodoma... | US Patent US9505780 (2016) BindingDB Entry DOI: 10.7270/Q22B8WZ1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (Homo sapiens (Human)) | BDBM50427457 (CHEMBL2326952 | US10308662, Compound 25 | US950578...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid PDB UniChem Similars | US Patent | n/a | n/a | 1.17E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer | Assay Description Inhibitory activity can be determined routinely using known methods and also from commercial vendors offering this service for kinases and bromodomai... | J Med Chem 50: 2647-54 (2007) BindingDB Entry DOI: 10.7270/Q24170D7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human)) | BDBM50427457 (CHEMBL2326952 | US10308662, Compound 25 | US950578...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid PDB UniChem Similars | US Patent | n/a | n/a | 714 | n/a | n/a | n/a | n/a | n/a | n/a |
SignalRx Pharmaceuticals, Inc. US Patent | Assay Description Several TP Scaffold compounds were tested for inhibition activity against isoforms of PI3K (alpha, beta, gamma, and delta isoforms) and the bromodoma... | US Patent US9505780 (2016) BindingDB Entry DOI: 10.7270/Q22B8WZ1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform (Homo sapiens (Human)) | BDBM50427457 (CHEMBL2326952 | US10308662, Compound 25 | US950578...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid PDB UniChem Similars | US Patent | n/a | n/a | 1.75E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
SignalRx Pharmaceuticals, Inc. US Patent | Assay Description Several TP Scaffold compounds were tested for inhibition activity against isoforms of PI3K (alpha, beta, gamma, and delta isoforms) and the bromodoma... | US Patent US9505780 (2016) BindingDB Entry DOI: 10.7270/Q22B8WZ1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human)) | BDBM50427457 (CHEMBL2326952 | US10308662, Compound 25 | US950578...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid PDB UniChem Similars | US Patent | n/a | n/a | 27 | n/a | n/a | n/a | n/a | n/a | n/a |
SignalRx Pharmaceuticals, Inc. US Patent | Assay Description Several TP Scaffold compounds were tested for inhibition activity against isoforms of PI3K (alpha, beta, gamma, and delta isoforms) and the bromodoma... | US Patent US9505780 (2016) BindingDB Entry DOI: 10.7270/Q22B8WZ1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (Homo sapiens (Human)) | BDBM50427457 (CHEMBL2326952 | US10308662, Compound 25 | US950578...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid PDB UniChem Similars | US Patent | n/a | n/a | 1.17E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
SignalRx Pharmaceuticals, Inc. US Patent | Assay Description Several TP Scaffold compounds were tested for inhibition activity against isoforms of PI3K (alpha, beta, gamma, and delta isoforms) and the bromodoma... | US Patent US9505780 (2016) BindingDB Entry DOI: 10.7270/Q22B8WZ1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (Homo sapiens (Human)) | BDBM50427457 (CHEMBL2326952 | US10308662, Compound 25 | US950578...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 1.17E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of Arizona Curated by ChEMBL | Assay Description Inhibition of PI3K p110gamma (unknown origin) | J Med Chem 56: 1922-39 (2013) Article DOI: 10.1021/jm301522m BindingDB Entry DOI: 10.7270/Q2Z89DR9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human)) | BDBM50427457 (CHEMBL2326952 | US10308662, Compound 25 | US950578...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 714 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of Arizona Curated by ChEMBL | Assay Description Inhibition of PI3K p110alpha (unknown origin) | J Med Chem 56: 1922-39 (2013) Article DOI: 10.1021/jm301522m BindingDB Entry DOI: 10.7270/Q2Z89DR9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human)) | BDBM50427457 (CHEMBL2326952 | US10308662, Compound 25 | US950578...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 27 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of Arizona Curated by ChEMBL | Assay Description Inhibition of PI3K p110delta (unknown origin) | J Med Chem 56: 1922-39 (2013) Article DOI: 10.1021/jm301522m BindingDB Entry DOI: 10.7270/Q2Z89DR9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform (Homo sapiens (Human)) | BDBM50427457 (CHEMBL2326952 | US10308662, Compound 25 | US950578...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 1.75E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of Arizona Curated by ChEMBL | Assay Description Inhibition of PI3K p110beta (unknown origin) | J Med Chem 56: 1922-39 (2013) Article DOI: 10.1021/jm301522m BindingDB Entry DOI: 10.7270/Q2Z89DR9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
BRD4 bromodomain 1 (Homo sapiens (Human)) | BDBM50427457 (CHEMBL2326952 | US10308662, Compound 25 | US950578...) | PDB MMDB B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid PDB UniChem Similars | PDB US Patent | n/a | n/a | 277 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer | Assay Description Inhibitory activity can be determined routinely using known methods and also from commercial vendors offering this service for kinases and bromodomai... | J Med Chem 50: 2647-54 (2007) BindingDB Entry DOI: 10.7270/Q24170D7 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
BRD4 bromodomain 2 (Homo sapiens (Human)) | BDBM50427457 (CHEMBL2326952 | US10308662, Compound 25 | US950578...) | PDB GoogleScholar AffyNet | CHEMBL PC cid PC sid PDB UniChem Similars | US Patent | n/a | n/a | 628 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer | Assay Description Inhibitory activity can be determined routinely using known methods and also from commercial vendors offering this service for kinases and bromodomai... | J Med Chem 50: 2647-54 (2007) BindingDB Entry DOI: 10.7270/Q24170D7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
PI3-kinase class I (Homo sapiens (Human)) | BDBM50427457 (CHEMBL2326952 | US10308662, Compound 25 | US950578...) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid PDB UniChem Similars | US Patent | n/a | n/a | 714 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer | Assay Description Inhibitory activity can be determined routinely using known methods and also from commercial vendors offering this service for kinases and bromodomai... | J Med Chem 50: 2647-54 (2007) BindingDB Entry DOI: 10.7270/Q24170D7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphatidylinositol 3-kinase regulatory subunit beta (Homo sapiens (Human)) | BDBM50427457 (CHEMBL2326952 | US10308662, Compound 25 | US950578...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid PDB UniChem Similars | US Patent | n/a | n/a | 1.75E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer | Assay Description Inhibitory activity can be determined routinely using known methods and also from commercial vendors offering this service for kinases and bromodomai... | J Med Chem 50: 2647-54 (2007) BindingDB Entry DOI: 10.7270/Q24170D7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human)) | BDBM50427457 (CHEMBL2326952 | US10308662, Compound 25 | US950578...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid PDB UniChem Similars | US Patent | n/a | n/a | 27 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer | Assay Description Inhibitory activity can be determined routinely using known methods and also from commercial vendors offering this service for kinases and bromodomai... | J Med Chem 50: 2647-54 (2007) BindingDB Entry DOI: 10.7270/Q24170D7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bromodomain-containing protein 4 Bromo 2 domain(BRD4 BD2) (Homo sapiens (Human)) | BDBM50427457 (CHEMBL2326952 | US10308662, Compound 25 | US950578...) | GoogleScholar AffyNet | CHEMBL PC cid PC sid PDB UniChem Similars | US Patent | n/a | n/a | 628 | n/a | n/a | n/a | n/a | n/a | n/a |
SignalRx Pharmaceuticals, Inc. US Patent | Assay Description Several TP Scaffold compounds were tested for inhibition activity against isoforms of PI3K (alpha, beta, gamma, and delta isoforms) and the bromodoma... | US Patent US9505780 (2016) BindingDB Entry DOI: 10.7270/Q22B8WZ1 | |||||||||||
More data for this Ligand-Target Pair |