BindingDB PrimarySearch

BDBM50428743 CHEMBL2333603

SMILES: CCCCn1c(cn2c1nc1n(C)c(=O)[nH]c(=O)c21)-c1ccccc1C

InChI Key: InChIKey=KCEWOOVCWCPFCY-UHFFFAOYSA-N

Data: 7 IC50

PDB links: 1 PDB ID matches this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50428743
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Tyrosine-protein kinase Yes (Homo sapiens (Human))	BDBM50428743 (CHEMBL2333603) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	284	n/a	n/a	n/a	n/a	n/a	n/a
University of Zurich Curated by ChEMBL					Assay Description Inhibition of Yes1 (unknown origin) using [gamma-33P]ATP after 30 mins by radiometric assay				J Med Chem 56: 84-96 (2013) Article DOI: 10.1021/jm301187e BindingDB Entry DOI: 10.7270/Q2WW7K1S
University of Zurich Curated by ChEMBL					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM50428743 (CHEMBL2333603) Show SMILES Show InChI	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	493	n/a	n/a	n/a	n/a	n/a	n/a
University of Zurich Curated by ChEMBL					Assay Description Inhibition of Lck (unknown origin) using [gamma-33P]ATP after 30 mins by radiometric assay				J Med Chem 56: 84-96 (2013) Article DOI: 10.1021/jm301187e BindingDB Entry DOI: 10.7270/Q2WW7K1S
University of Zurich Curated by ChEMBL					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human))	BDBM50428743 (CHEMBL2333603) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	71	n/a	n/a	n/a	n/a	n/a	n/a
University of Zurich Curated by ChEMBL					Assay Description Inhibition of Src (unknown origin) using [gamma-33P]ATP after 30 mins by radiometric assay				J Med Chem 56: 84-96 (2013) Article DOI: 10.1021/jm301187e BindingDB Entry DOI: 10.7270/Q2WW7K1S
University of Zurich Curated by ChEMBL					More data for this Ligand-Target Pair
Ephrin type-B receptor 4 (Homo sapiens (Human))	BDBM50428743 (CHEMBL2333603) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	50	n/a	n/a	n/a	n/a	n/a	n/a
University of Zurich Curated by ChEMBL					Assay Description Inhibition of human myc-tagged full length EphB4 expressed in MEF cells assessed as inhibition of ephrinB2-Fc-induced autophosphorylation incubated f...				J Med Chem 56: 84-96 (2013) Article DOI: 10.1021/jm301187e BindingDB Entry DOI: 10.7270/Q2WW7K1S
University of Zurich Curated by ChEMBL					More data for this Ligand-Target Pair
Ephrin type-B receptor 4 (Homo sapiens (Human))	BDBM50428743 (CHEMBL2333603) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	56	n/a	n/a	n/a	n/a	n/a	n/a
University of Zurich Curated by ChEMBL					Assay Description Inhibition of EphB4 (unknown origin) transfected in CHO cells using Z'-LYTE TYR-1 peptide as substrate after 2 hrs by FRET assay				J Med Chem 56: 84-96 (2013) Article DOI: 10.1021/jm301187e BindingDB Entry DOI: 10.7270/Q2WW7K1S
University of Zurich Curated by ChEMBL					More data for this Ligand-Target Pair
Ephrin type-B receptor 4 (Homo sapiens (Human))	BDBM50428743 (CHEMBL2333603) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	82	n/a	n/a	n/a	n/a	n/a	n/a
University of Zurich Curated by ChEMBL					Assay Description Inhibition of EphB4 (unknown origin) transfected in CHO cells using [gamma-33P]ATP by radiometric assay				J Med Chem 56: 84-96 (2013) Article DOI: 10.1021/jm301187e BindingDB Entry DOI: 10.7270/Q2WW7K1S
University of Zurich Curated by ChEMBL					More data for this Ligand-Target Pair
Tyrosine-protein kinase ABL1 (Homo sapiens (Human))	BDBM50428743 (CHEMBL2333603) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	578	n/a	n/a	n/a	n/a	n/a	n/a
University of Zurich Curated by ChEMBL					Assay Description Inhibition of Abl (unknown origin) using [gamma-33P]ATP after 30 mins by radiometric assay				J Med Chem 56: 84-96 (2013) Article DOI: 10.1021/jm301187e BindingDB Entry DOI: 10.7270/Q2WW7K1S
University of Zurich Curated by ChEMBL					More data for this Ligand-Target Pair