BDBM50429613 CHEMBL2334590

SMILES: Cc1nc2ccc(Cl)cn2c1-c1ccnc(N)n1

InChI Key: InChIKey=HLCLCIHQZZSHDC-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50429613   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Phosphoinositide 3-Kinase (PI3K), delta (Homo sapiens (Human))	BDBM50429613 (CHEMBL2334590) Show SMILES Cc1nc2ccc(Cl)cn2c1-c1ccnc(N)n1 Show InChI InChI=1S/C12H10ClN5/c1-7-11(9-4-5-15-12(14)17-9)18-6-8(13)2-3-10(18)16-7/h2-6H,1H3,(H2,14,15,17)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	2.57E+3	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Research& Development Curated by ChEMBL					Assay Description Inhibition of human full length recombinant His-tagged PIK3CD/PIK3R1 expressed in baculovirus expression system after 60 mins by LanthaScreen Eu bind...				J Med Chem 59: 4302-13 (2016) BindingDB Entry DOI: 10.7270/Q2DN46ZF
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 14 (Homo sapiens (Human))	BDBM50429613 (CHEMBL2334590) Show SMILES Cc1nc2ccc(Cl)cn2c1-c1ccnc(N)n1 Show InChI InChI=1S/C12H10ClN5/c1-7-11(9-4-5-15-12(14)17-9)18-6-8(13)2-3-10(18)16-7/h2-6H,1H3,(H2,14,15,17)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	600	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of NIK (unknown origin) autophosphorylation after 1 hr by chemiluminescent assay				Bioorg Med Chem Lett 23: 1238-44 (2013) Article DOI: 10.1016/j.bmcl.2013.01.012 BindingDB Entry DOI: 10.7270/Q2J967RQ
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 14 (Homo sapiens (Human))	BDBM50429613 (CHEMBL2334590) Show SMILES Cc1nc2ccc(Cl)cn2c1-c1ccnc(N)n1 Show InChI InChI=1S/C12H10ClN5/c1-7-11(9-4-5-15-12(14)17-9)18-6-8(13)2-3-10(18)16-7/h2-6H,1H3,(H2,14,15,17)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.60E+4	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of NIK in human HT-29 cells assessed as LTalpha/beta2-induced p100 processing to NFkappaB2 preincubated for 30 mins before LTalpha/beta2 s...				Bioorg Med Chem Lett 23: 1238-44 (2013) Article DOI: 10.1016/j.bmcl.2013.01.012 BindingDB Entry DOI: 10.7270/Q2J967RQ
					More data for this Ligand-Target Pair