BDBM50430131 CHEMBL2338255

SMILES: CC1(C)CCN([C@H]2C3CC4CC2C[C@@](O)(C4)C3)C(=O)c2cnn(c12)-c1ccc(cc1)C(F)(F)F

InChI Key: InChIKey=SRZJPLQHGQKYHU-JWCGBNDWSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50430131   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human))	BDBM50430131 (CHEMBL2338255) Show SMILES CC1(C)CCN([C@H]2C3CC4CC2C[C@@](O)(C4)C3)C(=O)c2cnn(c12)-c1ccc(cc1)C(F)(F)F |r,wU:6.5,13.14,TLB:10:9:16:12.11.6,10:11:15.9.8:16,6:7:15:12.10.11,THB:6:11:15:8.7.16,5:6:15.9.8:16,(34.61,-12.4,;35.25,-13.8,;35.64,-12.3,;36.78,-13.85,;37.71,-15.07,;37.34,-16.57,;38.52,-17.56,;39.91,-16.97,;40.96,-18.19,;40.97,-19.78,;39.57,-20.35,;38.54,-19.08,;39.94,-19.42,;41.26,-18.92,;42.8,-18.9,;42.47,-20.18,;41.26,-17.43,;35.94,-17.2,;35.9,-18.74,;34.56,-16.5,;33.22,-17.26,;32.08,-16.22,;32.72,-14.81,;34.26,-14.99,;31.96,-13.48,;32.75,-12.15,;31.99,-10.81,;30.45,-10.8,;29.67,-12.14,;30.43,-13.47,;29.69,-9.46,;30.47,-8.13,;28.15,-9.45,;28.9,-8.12,)| Show InChI InChI=1S/C26H30F3N3O2/c1-24(2)7-8-31(21-16-9-15-10-17(21)13-25(34,11-15)12-16)23(33)20-14-30-32(22(20)24)19-5-3-18(4-6-19)26(27,28)29/h3-6,14-17,21,34H,7-13H2,1-2H3/t15?,16?,17?,21-,25+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
Toray Industries, Inc. Curated by ChEMBL					Assay Description Inhibition of 11beta-HSD1 in human liver microsomes using cortisone and NADPH as substrate by HTRF assay				Bioorg Med Chem Lett 23: 1617-21 (2013) Article DOI: 10.1016/j.bmcl.2013.01.090 BindingDB Entry DOI: 10.7270/Q27P90RZ
					More data for this Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1 (Mus musculus (mouse))	BDBM50430131 (CHEMBL2338255) Show SMILES CC1(C)CCN([C@H]2C3CC4CC2C[C@@](O)(C4)C3)C(=O)c2cnn(c12)-c1ccc(cc1)C(F)(F)F |r,wU:6.5,13.14,TLB:10:9:16:12.11.6,10:11:15.9.8:16,6:7:15:12.10.11,THB:6:11:15:8.7.16,5:6:15.9.8:16,(34.61,-12.4,;35.25,-13.8,;35.64,-12.3,;36.78,-13.85,;37.71,-15.07,;37.34,-16.57,;38.52,-17.56,;39.91,-16.97,;40.96,-18.19,;40.97,-19.78,;39.57,-20.35,;38.54,-19.08,;39.94,-19.42,;41.26,-18.92,;42.8,-18.9,;42.47,-20.18,;41.26,-17.43,;35.94,-17.2,;35.9,-18.74,;34.56,-16.5,;33.22,-17.26,;32.08,-16.22,;32.72,-14.81,;34.26,-14.99,;31.96,-13.48,;32.75,-12.15,;31.99,-10.81,;30.45,-10.8,;29.67,-12.14,;30.43,-13.47,;29.69,-9.46,;30.47,-8.13,;28.15,-9.45,;28.9,-8.12,)| Show InChI InChI=1S/C26H30F3N3O2/c1-24(2)7-8-31(21-16-9-15-10-17(21)13-25(34,11-15)12-16)23(33)20-14-30-32(22(20)24)19-5-3-18(4-6-19)26(27,28)29/h3-6,14-17,21,34H,7-13H2,1-2H3/t15?,16?,17?,21-,25+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	29	n/a	n/a	n/a	n/a	n/a	n/a
Toray Industries, Inc. Curated by ChEMBL					Assay Description Inhibition of mouse 11beta-HSD1 expressed in HEK293 cells using cortisone and NADPH as substrate by HTRF assay				Bioorg Med Chem Lett 23: 1617-21 (2013) Article DOI: 10.1016/j.bmcl.2013.01.090 BindingDB Entry DOI: 10.7270/Q27P90RZ
					More data for this Ligand-Target Pair