BDBM50430142 CHEMBL2338244

SMILES: CC1(C)CCN([C@H]2C3CC4CC2C[C@@](O)(C4)C3)C(=O)c2cnn(c12)-c1ccccn1

InChI Key: InChIKey=JIFHNJNJKQBZGU-MALZWFGSSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50430142   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
11-beta-hydroxysteroid dehydrogenase 1 (Mus musculus (mouse))	BDBM50430142 (CHEMBL2338244) Show SMILES CC1(C)CCN([C@H]2C3CC4CC2C[C@@](O)(C4)C3)C(=O)c2cnn(c12)-c1ccccn1 |r,wU:6.5,13.14,TLB:10:9:16:12.11.6,10:11:15.9.8:16,6:7:15:12.10.11,THB:6:11:15:8.7.16,5:6:15.9.8:16,(8.51,-43.7,;8.91,-45.2,;9.67,-43.86,;10.44,-45.24,;11.38,-46.47,;11.01,-47.96,;12.18,-48.95,;13.57,-48.36,;14.62,-49.58,;14.63,-51.16,;13.23,-51.74,;12.21,-50.47,;13.6,-50.81,;14.93,-50.31,;16.46,-50.29,;16.13,-51.57,;14.92,-48.82,;9.6,-48.59,;9.57,-50.13,;8.23,-47.89,;6.89,-48.65,;5.76,-47.61,;6.39,-46.2,;7.93,-46.38,;5.64,-44.88,;6.42,-43.55,;5.66,-42.21,;4.12,-42.2,;3.34,-43.53,;4.11,-44.87,)| Show InChI InChI=1S/C24H30N4O2/c1-23(2)6-8-27(20-16-9-15-10-17(20)13-24(30,11-15)12-16)22(29)18-14-26-28(21(18)23)19-5-3-4-7-25-19/h3-5,7,14-17,20,30H,6,8-13H2,1-2H3/t15?,16?,17?,20-,24+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>100	n/a	n/a	n/a	n/a	n/a	n/a
Toray Industries, Inc. Curated by ChEMBL					Assay Description Inhibition of mouse 11beta-HSD1 expressed in HEK293 cells using cortisone and NADPH as substrate by HTRF assay				Bioorg Med Chem Lett 23: 1617-21 (2013) Article DOI: 10.1016/j.bmcl.2013.01.090 BindingDB Entry DOI: 10.7270/Q27P90RZ
					More data for this Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human))	BDBM50430142 (CHEMBL2338244) Show SMILES CC1(C)CCN([C@H]2C3CC4CC2C[C@@](O)(C4)C3)C(=O)c2cnn(c12)-c1ccccn1 |r,wU:6.5,13.14,TLB:10:9:16:12.11.6,10:11:15.9.8:16,6:7:15:12.10.11,THB:6:11:15:8.7.16,5:6:15.9.8:16,(8.51,-43.7,;8.91,-45.2,;9.67,-43.86,;10.44,-45.24,;11.38,-46.47,;11.01,-47.96,;12.18,-48.95,;13.57,-48.36,;14.62,-49.58,;14.63,-51.16,;13.23,-51.74,;12.21,-50.47,;13.6,-50.81,;14.93,-50.31,;16.46,-50.29,;16.13,-51.57,;14.92,-48.82,;9.6,-48.59,;9.57,-50.13,;8.23,-47.89,;6.89,-48.65,;5.76,-47.61,;6.39,-46.2,;7.93,-46.38,;5.64,-44.88,;6.42,-43.55,;5.66,-42.21,;4.12,-42.2,;3.34,-43.53,;4.11,-44.87,)| Show InChI InChI=1S/C24H30N4O2/c1-23(2)6-8-27(20-16-9-15-10-17(20)13-24(30,11-15)12-16)22(29)18-14-26-28(21(18)23)19-5-3-4-7-25-19/h3-5,7,14-17,20,30H,6,8-13H2,1-2H3/t15?,16?,17?,20-,24+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
Toray Industries, Inc. Curated by ChEMBL					Assay Description Inhibition of 11beta-HSD1 in human liver microsomes using cortisone and NADPH as substrate by HTRF assay				Bioorg Med Chem Lett 23: 1617-21 (2013) Article DOI: 10.1016/j.bmcl.2013.01.090 BindingDB Entry DOI: 10.7270/Q27P90RZ
					More data for this Ligand-Target Pair