BDBM50431004 CHEMBL2337885

SMILES: CC[C@H](C)[C@H]1[C@@H](OC1=O)C(=O)N[C@H]1C[C@H]1C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)OCc1ccccc1)C=C

InChI Key: InChIKey=DVDFLRFFPGRAFH-LWIGSKBWSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50431004   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
20S proteasome chymotrypsin-like (Homo sapiens (Human))	BDBM50431004 (CHEMBL2337885) Show SMILES CC[C@H](C)[C@H]1[C@@H](OC1=O)C(=O)N[C@H]1C[C@H]1C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)OCc1ccccc1)C=C |r| Show InChI InChI=1S/C29H41N3O6/c1-6-18(5)24-25(38-28(24)35)27(34)31-22-15-20(22)14-21(7-2)30-26(33)23(13-17(3)4)32-29(36)37-16-19-11-9-8-10-12-19/h7-12,17-18,20-25H,2,6,13-16H2,1,3-5H3,(H,30,33)(H,31,34)(H,32,36)/t18-,20+,21+,22-,23-,24-,25+/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	47	n/a	n/a	n/a	n/a	n/a	n/a
Hokkaido University Curated by ChEMBL					Assay Description Inhibition of chymotrypsin-like activity of human 20S proteasome beta 5 subunit using Suc-LLVY-AMC as substrate after 60 mins by fluorescence assay				J Med Chem 56: 3689-700 (2013) Article DOI: 10.1021/jm4002296 BindingDB Entry DOI: 10.7270/Q25M673W
					More data for this Ligand-Target Pair