Found 3 hits for monomerid = 50433035 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (PI3K alpha)
(Mus musculus (Mouse)) | BDBM50433035
(CHEMBL2375954 | US8633204, 313)Show SMILES Cc1nc(N)nc2n([C@H]3CC[C@@H](CC3)OCC(N)=O)c(=O)c(cc12)-c1cnn(C)c1 |r,wU:11.14,wD:8.7,(54.35,-45.06,;54.35,-46.6,;53.02,-47.37,;53.02,-48.92,;51.69,-49.69,;54.36,-49.69,;55.69,-48.92,;57.02,-49.7,;57.02,-51.23,;55.68,-52,;55.67,-53.53,;57,-54.31,;58.34,-53.55,;58.35,-52,;56.99,-55.85,;55.65,-56.61,;54.32,-55.83,;52.98,-56.6,;54.33,-54.29,;58.37,-48.93,;59.71,-49.7,;58.38,-47.37,;57.03,-46.59,;55.69,-47.37,;59.71,-46.61,;61.11,-47.25,;62.14,-46.12,;61.39,-44.78,;62.02,-43.38,;59.88,-45.09,)| Show InChI InChI=1S/C20H25N7O3/c1-11-15-7-16(12-8-23-26(2)9-12)19(29)27(18(15)25-20(22)24-11)13-3-5-14(6-4-13)30-10-17(21)28/h7-9,13-14H,3-6,10H2,1-2H3,(H2,21,28)(H2,22,24,25)/t13-,14- | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 22 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description Inhibition of mouse PI3Kalpha |
Bioorg Med Chem Lett 23: 2787-92 (2013)
Article DOI: 10.1016/j.bmcl.2013.02.020 BindingDB Entry DOI: 10.7270/Q2NZ890X |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM50433035
(CHEMBL2375954 | US8633204, 313)Show SMILES Cc1nc(N)nc2n([C@H]3CC[C@@H](CC3)OCC(N)=O)c(=O)c(cc12)-c1cnn(C)c1 |r,wU:11.14,wD:8.7,(54.35,-45.06,;54.35,-46.6,;53.02,-47.37,;53.02,-48.92,;51.69,-49.69,;54.36,-49.69,;55.69,-48.92,;57.02,-49.7,;57.02,-51.23,;55.68,-52,;55.67,-53.53,;57,-54.31,;58.34,-53.55,;58.35,-52,;56.99,-55.85,;55.65,-56.61,;54.32,-55.83,;52.98,-56.6,;54.33,-54.29,;58.37,-48.93,;59.71,-49.7,;58.38,-47.37,;57.03,-46.59,;55.69,-47.37,;59.71,-46.61,;61.11,-47.25,;62.14,-46.12,;61.39,-44.78,;62.02,-43.38,;59.88,-45.09,)| Show InChI InChI=1S/C20H25N7O3/c1-11-15-7-16(12-8-23-26(2)9-12)19(29)27(18(15)25-20(22)24-11)13-3-5-14(6-4-13)30-10-17(21)28/h7-9,13-14H,3-6,10H2,1-2H3,(H2,21,28)(H2,22,24,25)/t13-,14- | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| US Patent
| n/a | n/a | 47.9 | n/a | n/a | n/a | n/a | 7.4 | 25 |
Pfizer Inc.
US Patent
| Assay Description Compounds of the present invention were evaluated for potency against PI3-Kα using an in vitro kinase assay. PI3-Kα activity is measured in... |
US Patent US8633204 (2014)
BindingDB Entry DOI: 10.7270/Q2Q81BQT |
More data for this Ligand-Target Pair | |
RAC-alpha serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50433035
(CHEMBL2375954 | US8633204, 313)Show SMILES Cc1nc(N)nc2n([C@H]3CC[C@@H](CC3)OCC(N)=O)c(=O)c(cc12)-c1cnn(C)c1 |r,wU:11.14,wD:8.7,(54.35,-45.06,;54.35,-46.6,;53.02,-47.37,;53.02,-48.92,;51.69,-49.69,;54.36,-49.69,;55.69,-48.92,;57.02,-49.7,;57.02,-51.23,;55.68,-52,;55.67,-53.53,;57,-54.31,;58.34,-53.55,;58.35,-52,;56.99,-55.85,;55.65,-56.61,;54.32,-55.83,;52.98,-56.6,;54.33,-54.29,;58.37,-48.93,;59.71,-49.7,;58.38,-47.37,;57.03,-46.59,;55.69,-47.37,;59.71,-46.61,;61.11,-47.25,;62.14,-46.12,;61.39,-44.78,;62.02,-43.38,;59.88,-45.09,)| Show InChI InChI=1S/C20H25N7O3/c1-11-15-7-16(12-8-23-26(2)9-12)19(29)27(18(15)25-20(22)24-11)13-3-5-14(6-4-13)30-10-17(21)28/h7-9,13-14H,3-6,10H2,1-2H3,(H2,21,28)(H2,22,24,25)/t13-,14- | PDB
UniProtKB/SwissProt UniProtKB/TrEMBL
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 376 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description Inhibition of AKT phosphorylation at Ser 473 in human BT20 cells |
Bioorg Med Chem Lett 23: 2787-92 (2013)
Article DOI: 10.1016/j.bmcl.2013.02.020 BindingDB Entry DOI: 10.7270/Q2NZ890X |
More data for this Ligand-Target Pair | |