BDBM50436208 CHEMBL2398572
SMILES: CC(C)CCC[C@@H](C)CCC[C@@H](C)CCC\C(C)=C\Cn1c2ccc(Cl)cc2c2ccc(cc12)C(C)C(O)=O
InChI Key: InChIKey=VXRDMDBFZQPZFB-HCKKOKALSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Presenilin-1 (Homo sapiens (Human)) | BDBM50436208![]() (CHEMBL2398572) | PDB MMDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Technische Universit£t Darmstadt Curated by ChEMBL | Assay Description Modulation of human gamma-secretase presenilin-1 subunit expressed in CHO cells coexpressing human APP assessed as decrease in amyloid beta 40 genera... | Bioorg Med Chem Lett 23: 3852-6 (2013) Article DOI: 10.1016/j.bmcl.2013.04.070 BindingDB Entry DOI: 10.7270/Q2DF6SMP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Presenilin-1 (Homo sapiens (Human)) | BDBM50436208![]() (CHEMBL2398572) | PDB MMDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | >5.00E+4 | n/a | n/a | n/a | n/a |
Technische Universit£t Darmstadt Curated by ChEMBL | Assay Description Modulation of human gamma-secretase presenilin-1 subunit expressed in CHO cells coexpressing human APP assessed as increase in amyloid beta 38 genera... | Bioorg Med Chem Lett 23: 3852-6 (2013) Article DOI: 10.1016/j.bmcl.2013.04.070 BindingDB Entry DOI: 10.7270/Q2DF6SMP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Presenilin-1 (Homo sapiens (Human)) | BDBM50436208![]() (CHEMBL2398572) | PDB MMDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2.30E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Technische Universit£t Darmstadt Curated by ChEMBL | Assay Description Modulation of human gamma-secretase presenilin-1 subunit expressed in CHO cells coexpressing human APP assessed as decrease in amyloid beta 42 genera... | Bioorg Med Chem Lett 23: 3852-6 (2013) Article DOI: 10.1016/j.bmcl.2013.04.070 BindingDB Entry DOI: 10.7270/Q2DF6SMP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Presenilin-1 (Homo sapiens (Human)) | BDBM50436208![]() (CHEMBL2398572) | PDB MMDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 3.98E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Technische Universit£t Darmstadt Curated by ChEMBL | Assay Description Modulation of human gamma-secretase presenilin-1 subunit expressed in CHO cells coexpressing human APP assessed as decrease in amyloid beta 42 genera... | Bioorg Med Chem Lett 23: 3852-6 (2013) Article DOI: 10.1016/j.bmcl.2013.04.070 BindingDB Entry DOI: 10.7270/Q2DF6SMP | |||||||||||
More data for this Ligand-Target Pair |