BDBM50437359 CHEMBL3037923

SMILES: CN1CCN(CC1)[C@H]1C[C@H](C1)c1nc(-c2ccc3c(Oc4ccccc4)cc(nc3c2F)-c2ccccc2)c2c(N)nccn12

InChI Key: InChIKey=OATYZLINYMVFFJ-PLQXJYEYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50437359   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Insulin-like growth factor I receptor (Homo sapiens (Human))	BDBM50437359 (CHEMBL3037923) Show SMILES CN1CCN(CC1)[C@H]1C[C@H](C1)c1nc(-c2ccc3c(Oc4ccccc4)cc(nc3c2F)-c2ccccc2)c2c(N)nccn12 |r,wU:9.12,7.7,(52.28,-55.94,;51.37,-54.69,;49.83,-54.85,;48.93,-53.61,;49.55,-52.21,;51.08,-52.03,;51.99,-53.28,;48.64,-50.96,;47.12,-50.73,;47.36,-49.21,;48.88,-49.44,;46.45,-47.97,;46.92,-46.5,;45.66,-45.6,;45.65,-44.06,;44.31,-43.29,;44.31,-41.75,;45.64,-40.98,;45.64,-39.43,;44.31,-38.66,;44.31,-37.12,;45.65,-36.35,;45.65,-34.81,;44.31,-34.04,;42.97,-34.82,;42.98,-36.36,;46.97,-38.66,;48.31,-39.43,;48.31,-40.98,;46.98,-41.75,;46.98,-43.28,;48.32,-44.05,;49.64,-38.65,;50.97,-39.42,;52.3,-38.65,;52.3,-37.1,;50.95,-36.34,;49.63,-37.12,;44.43,-46.52,;42.93,-46.2,;42.46,-44.73,;41.9,-47.34,;42.38,-48.8,;43.89,-49.12,;44.91,-47.98,)| Show InChI InChI=1S/C36H34FN7O/c1-42-16-18-43(19-17-42)25-20-24(21-25)36-41-33(34-35(38)39-14-15-44(34)36)28-13-12-27-30(45-26-10-6-3-7-11-26)22-29(40-32(27)31(28)37)23-8-4-2-5-9-23/h2-15,22,24-25H,16-21H2,1H3,(H2,38,39)/t24-,25+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	72	n/a	n/a	n/a	n/a	n/a	n/a
OSI Pharmaceuticals, LLC Curated by ChEMBL					Assay Description Inhibition of full length human IGF-1R overexpressed in mouse NIH 3T3 cells assessed as IGF1-induced protein phosphorylation incubated for 2 hrs prio...				ACS Med Chem Lett 4: 627-31 (2013) Article DOI: 10.1021/ml400160a BindingDB Entry DOI: 10.7270/Q2S75HR4
					More data for this Ligand-Target Pair