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BDBM50437372 CHEMBL3037910

SMILES: CC(C)Oc1cc(nc2cc(ccc12)-c1nc([C@H]2C[C@@](C)(O)C2)n2ccnc(N)c12)-c1ccccc1

InChI Key: InChIKey=HSCSCGOSCLPFHX-VTNQZFKNSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50437372   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Insulin-like growth factor I receptor


(Homo sapiens (Human))		BDBM50437372
PNG
(CHEMBL3037910)
Show SMILES CC(C)Oc1cc(nc2cc(ccc12)-c1nc([C@H]2C[C@@](C)(O)C2)n2ccnc(N)c12)-c1ccccc1 |r,wU:19.22,17.18,wD:19.21,(26.66,-.05,;25.33,-.82,;23.99,-.05,;25.33,-2.36,;26.66,-3.13,;27.99,-2.36,;29.33,-3.12,;29.34,-4.68,;28,-5.45,;28,-6.98,;26.68,-7.76,;25.33,-6.99,;25.33,-5.45,;26.66,-4.68,;26.69,-9.3,;27.94,-10.2,;27.47,-11.67,;28.38,-12.91,;29.9,-13.14,;29.66,-14.66,;31.15,-15.06,;30.06,-16.15,;28.15,-14.43,;25.93,-11.68,;24.91,-12.82,;23.4,-12.5,;22.93,-11.04,;23.96,-9.9,;23.48,-8.43,;25.45,-10.21,;30.66,-2.35,;32,-3.12,;33.33,-2.34,;33.32,-.8,;31.98,-.04,;30.65,-.81,)|
Show InChI InChI=1S/C29H29N5O2/c1-17(2)36-24-14-22(18-7-5-4-6-8-18)32-23-13-19(9-10-21(23)24)25-26-27(30)31-11-12-34(26)28(33-25)20-15-29(3,35)16-20/h4-14,17,20,35H,15-16H2,1-3H3,(H2,30,31)/t20-,29+
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n/an/a 10n/an/an/an/an/an/a



OSI Pharmaceuticals, LLC

Curated by ChEMBL


Assay Description
Inhibition of full length human IGF-1R overexpressed in mouse NIH 3T3 cells assessed as IGF1-induced protein phosphorylation incubated for 2 hrs prio...

ACS Med Chem Lett 4: 627-31 (2013)


Article DOI: 10.1021/ml400160a
BindingDB Entry DOI: 10.7270/Q2S75HR4
More data for this
Ligand-Target Pair