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SMILES: Cc1nnc(-c2ccc(cc2)-c2ccccn2)n1-c1ccccc1F

InChI Key: InChIKey=WRYCGINDUVPELG-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50439751   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Sodium- and chloride-dependent glycine transporter 2 (Rattus norvegicus)	BDBM50439751 (CHEMBL2419444) Show SMILES Cc1nnc(-c2ccc(cc2)-c2ccccn2)n1-c1ccccc1F |(16.51,-26.63,;15.04,-26.16,;14.56,-24.69,;13.02,-24.7,;12.55,-26.16,;11.22,-26.92,;9.89,-26.14,;8.55,-26.9,;8.54,-28.44,;9.88,-29.22,;11.21,-28.46,;7.21,-29.2,;5.88,-28.42,;4.54,-29.18,;4.53,-30.73,;5.87,-31.5,;7.2,-30.74,;13.8,-27.07,;13.8,-28.6,;12.47,-29.38,;12.47,-30.92,;13.8,-31.69,;15.14,-30.92,;15.14,-29.37,;16.47,-28.59,)| Show InChI InChI=1S/C20H15FN4/c1-14-23-24-20(25(14)19-8-3-2-6-17(19)21)16-11-9-15(10-12-16)18-7-4-5-13-22-18/h2-13H,1H3	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
Astellas Pharma Inc. Curated by ChEMBL					Assay Description Displacement of [3H]glycine from GlyT2 in Wistar rat brainstem cells after 10 mins by scintillation counting analysis				J Med Chem 56: 5744-56 (2014) Article DOI: 10.1021/jm400383w BindingDB Entry DOI: 10.7270/Q2D79CVX
					More data for this Ligand-Target Pair
Sodium- and chloride-dependent glycine transporter 1 (attus norvegicus (Rat))	BDBM50439751 (CHEMBL2419444) Show SMILES Cc1nnc(-c2ccc(cc2)-c2ccccn2)n1-c1ccccc1F |(16.51,-26.63,;15.04,-26.16,;14.56,-24.69,;13.02,-24.7,;12.55,-26.16,;11.22,-26.92,;9.89,-26.14,;8.55,-26.9,;8.54,-28.44,;9.88,-29.22,;11.21,-28.46,;7.21,-29.2,;5.88,-28.42,;4.54,-29.18,;4.53,-30.73,;5.87,-31.5,;7.2,-30.74,;13.8,-27.07,;13.8,-28.6,;12.47,-29.38,;12.47,-30.92,;13.8,-31.69,;15.14,-30.92,;15.14,-29.37,;16.47,-28.59,)| Show InChI InChI=1S/C20H15FN4/c1-14-23-24-20(25(14)19-8-3-2-6-17(19)21)16-11-9-15(10-12-16)18-7-4-5-13-22-18/h2-13H,1H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	860	n/a	n/a	n/a	n/a	n/a	n/a
Astellas Pharma Inc. Curated by ChEMBL					Assay Description Displacement of [3H]glycine from GlyT1 in rat C6 glioma cells incubated for 30 mins prior to substrate addition measured after 10 mins by scintillati...				J Med Chem 56: 5744-56 (2014) Article DOI: 10.1021/jm400383w BindingDB Entry DOI: 10.7270/Q2D79CVX
					More data for this Ligand-Target Pair