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BDBM50442658 CHEMBL2442018

SMILES: CCN([C@H]1CCC[C@@H](N)C1)C(=O)c1ccccc1OCc1ccccc1F

InChI Key: InChIKey=ZDXREZFNPUOZCQ-MSOLQXFVSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50442658   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Transient receptor potential cation channel subfamily M member 8 (TRPM8)


(Homo sapiens (Human))		BDBM50442658
PNG
(CHEMBL2442018)
Show SMILES CCN([C@H]1CCC[C@@H](N)C1)C(=O)c1ccccc1OCc1ccccc1F |r|
Show InChI InChI=1S/C22H27FN2O2/c1-2-25(18-10-7-9-17(24)14-18)22(26)19-11-4-6-13-21(19)27-15-16-8-3-5-12-20(16)23/h3-6,8,11-13,17-18H,2,7,9-10,14-15,24H2,1H3/t17-,18+/m1/s1
KEGG

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UniProtKB/TrEMBL

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PC cid
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UniChem

Similars
Article
PubMed
n/an/a 435n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human TRPM8 (unknown origin) expressed in HEK293 cells assessed as inhibition of WS12-induced Ca2+ elevation by FLIPR assay

Bioorg Med Chem Lett 23: 6118-22 (2013)


Article DOI: 10.1016/j.bmcl.2013.09.016
BindingDB Entry DOI: 10.7270/Q2125V4N
More data for this
Ligand-Target Pair