BDBM50444206 CHEMBL3093453
SMILES: Cc1cc(C)c(c(C)c1)S(=O)(=O)NC(Cc1c[nH]c2c(cc(C)cc12)C#N)C(F)(F)F
InChI Key: InChIKey=CEOIQIXVRWVLBN-UHFFFAOYSA-N
Data: 4 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Progesterone receptor (Homo sapiens (Human)) | BDBM50444206 (CHEMBL3093453) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 750 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim Pharmaceuticals Inc. Curated by ChEMBL | Assay Description Displacement of TAMRA-labeled mifepristone from progesterone receptor (unknown origin) by fluorescence polarization competitive binding assay | Bioorg Med Chem Lett 23: 6640-4 (2013) Article DOI: 10.1016/j.bmcl.2013.10.052 BindingDB Entry DOI: 10.7270/Q2DN46G5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glucocorticoid receptor (Homo sapiens (Human)) | BDBM50444206 (CHEMBL3093453) | PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim Pharmaceuticals Inc. Curated by ChEMBL | Assay Description Displacement of TAMRA-labeled dexamethasone from glucocorticoid receptor (unknown origin) by fluorescence polarization competitive binding assay | Bioorg Med Chem Lett 23: 6640-4 (2013) Article DOI: 10.1016/j.bmcl.2013.10.052 BindingDB Entry DOI: 10.7270/Q2DN46G5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glucocorticoid receptor (Homo sapiens (Human)) | BDBM50444206 (CHEMBL3093453) | PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 15 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim Pharmaceuticals Inc. Curated by ChEMBL | Assay Description Agonist activity at glucocorticoid receptor in HFF assessed as inhibition of IL-1-induced IL-6 production after 24 hrs | Bioorg Med Chem Lett 23: 6640-4 (2013) Article DOI: 10.1016/j.bmcl.2013.10.052 BindingDB Entry DOI: 10.7270/Q2DN46G5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mineralocorticoid receptor (Homo sapiens (Human)) | BDBM50444206 (CHEMBL3093453) | PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 110 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim Pharmaceuticals Inc. Curated by ChEMBL | Assay Description Binding affinity to mineralocorticoid receptor (unknown origin) by fluorescence polarization competitive binding assay | Bioorg Med Chem Lett 23: 6640-4 (2013) Article DOI: 10.1016/j.bmcl.2013.10.052 BindingDB Entry DOI: 10.7270/Q2DN46G5 | |||||||||||
More data for this Ligand-Target Pair |