Found 6 hits for monomerid = 50447079 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
RAC-alpha serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50447079
![PNG](/data/jpeg/tenK5044/BindingDB_50447079.png) (CHEMBL3112859 | US9133168, Example 26d)Show SMILES CN1CCN(CC1)c1cccc2N(CCc12)C(=O)Cc1nc(cc(=O)[nH]1)N1CCOCC1 Show InChI InChI=1S/C23H30N6O3/c1-26-7-9-27(10-8-26)18-3-2-4-19-17(18)5-6-29(19)23(31)15-20-24-21(16-22(30)25-20)28-11-13-32-14-12-28/h2-4,16H,5-15H2,1H3,(H,24,25,30) | PDB
UniProtKB/SwissProt UniProtKB/TrEMBL
antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| US Patent
| n/a | n/a | 167 | n/a | n/a | n/a | n/a | n/a | n/a |
SANOFI
US Patent
| Assay Description This test is based on measurement of the expression of AKT protein phosphorylated on serine 473 (P-AKT-S473) in the PC3 human prostate carcinoma line... |
US Patent US9133168 (2015)
BindingDB Entry DOI: 10.7270/Q29W0D8X |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
(Homo sapiens (Human)) | BDBM50447079
![PNG](/data/jpeg/tenK5044/BindingDB_50447079.png) (CHEMBL3112859 | US9133168, Example 26d)Show SMILES CN1CCN(CC1)c1cccc2N(CCc12)C(=O)Cc1nc(cc(=O)[nH]1)N1CCOCC1 Show InChI InChI=1S/C23H30N6O3/c1-26-7-9-27(10-8-26)18-3-2-4-19-17(18)5-6-29(19)23(31)15-20-24-21(16-22(30)25-20)28-11-13-32-14-12-28/h2-4,16H,5-15H2,1H3,(H,24,25,30) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 407 | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi
Curated by ChEMBL
| Assay Description Inhibition of N-terminal ploy-His-tagged human PI3Kbeta expressed in baculovirus-infected sf21 cells using PI(4,5)P2 as substrate after 15 mins by HT... |
J Med Chem 57: 903-20 (2014)
Article DOI: 10.1021/jm401642q BindingDB Entry DOI: 10.7270/Q2R212VJ |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
(Homo sapiens (Human)) | BDBM50447079
![PNG](/data/jpeg/tenK5044/BindingDB_50447079.png) (CHEMBL3112859 | US9133168, Example 26d)Show SMILES CN1CCN(CC1)c1cccc2N(CCc12)C(=O)Cc1nc(cc(=O)[nH]1)N1CCOCC1 Show InChI InChI=1S/C23H30N6O3/c1-26-7-9-27(10-8-26)18-3-2-4-19-17(18)5-6-29(19)23(31)15-20-24-21(16-22(30)25-20)28-11-13-32-14-12-28/h2-4,16H,5-15H2,1H3,(H,24,25,30) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi
Curated by ChEMBL
| Assay Description Inhibition of C-terminal ploy-His-tagged human PI3Kgamma expressed in baculovirus-infected sf9 cells using PI(4,5)P2 as substrate after 15 mins by HT... |
J Med Chem 57: 903-20 (2014)
Article DOI: 10.1021/jm401642q BindingDB Entry DOI: 10.7270/Q2R212VJ |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM50447079
![PNG](/data/jpeg/tenK5044/BindingDB_50447079.png) (CHEMBL3112859 | US9133168, Example 26d)Show SMILES CN1CCN(CC1)c1cccc2N(CCc12)C(=O)Cc1nc(cc(=O)[nH]1)N1CCOCC1 Show InChI InChI=1S/C23H30N6O3/c1-26-7-9-27(10-8-26)18-3-2-4-19-17(18)5-6-29(19)23(31)15-20-24-21(16-22(30)25-20)28-11-13-32-14-12-28/h2-4,16H,5-15H2,1H3,(H,24,25,30) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 960 | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi
Curated by ChEMBL
| Assay Description Inhibition of N-terminal ploy-His-tagged human PI3Kalpha expressed in baculovirus-infected sf9 cells using PI(4,5)P2 as substrate after 15 mins by HT... |
J Med Chem 57: 903-20 (2014)
Article DOI: 10.1021/jm401642q BindingDB Entry DOI: 10.7270/Q2R212VJ |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
(Homo sapiens (Human)) | BDBM50447079
![PNG](/data/jpeg/tenK5044/BindingDB_50447079.png) (CHEMBL3112859 | US9133168, Example 26d)Show SMILES CN1CCN(CC1)c1cccc2N(CCc12)C(=O)Cc1nc(cc(=O)[nH]1)N1CCOCC1 Show InChI InChI=1S/C23H30N6O3/c1-26-7-9-27(10-8-26)18-3-2-4-19-17(18)5-6-29(19)23(31)15-20-24-21(16-22(30)25-20)28-11-13-32-14-12-28/h2-4,16H,5-15H2,1H3,(H,24,25,30) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 167 | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi
Curated by ChEMBL
| Assay Description Inhibition of N-terminal ploy-His-tagged human PI3Kbeta expressed in baculovirus-infected sf21 cells using PI(4,5)P2 as substrate after 15 mins by HT... |
J Med Chem 57: 903-20 (2014)
Article DOI: 10.1021/jm401642q BindingDB Entry DOI: 10.7270/Q2R212VJ |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
(Homo sapiens (Human)) | BDBM50447079
![PNG](/data/jpeg/tenK5044/BindingDB_50447079.png) (CHEMBL3112859 | US9133168, Example 26d)Show SMILES CN1CCN(CC1)c1cccc2N(CCc12)C(=O)Cc1nc(cc(=O)[nH]1)N1CCOCC1 Show InChI InChI=1S/C23H30N6O3/c1-26-7-9-27(10-8-26)18-3-2-4-19-17(18)5-6-29(19)23(31)15-20-24-21(16-22(30)25-20)28-11-13-32-14-12-28/h2-4,16H,5-15H2,1H3,(H,24,25,30) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 22 | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi
Curated by ChEMBL
| Assay Description Inhibition of N-terminal ploy-His-tagged human PI3Kdelta expressed in baculovirus-infected sf9 cells using PI(4,5)P2 as substrate after 15 mins by HT... |
J Med Chem 57: 903-20 (2014)
Article DOI: 10.1021/jm401642q BindingDB Entry DOI: 10.7270/Q2R212VJ |
More data for this Ligand-Target Pair | |