BindingDB PrimarySearch

BDBM50448896 CHEMBL3125307

SMILES: O=C(CCCCCCc1ccccc1)c1ncc(o1)-c1ccc(CC#N)cn1

InChI Key: InChIKey=MDHSRBKWWXIDHJ-UHFFFAOYSA-N

Data: 4 KI 4 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50448896
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Fatty-acid amide hydrolase 1 (aa 30-579) (Rattus norvegicus (rat))	BDBM50448896 (CHEMBL3125307) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	0.5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
The Scripps Research Institute Curated by ChEMBL					Assay Description Time-dependent inhibition of recombinant rat FAAH expressed in Escherichia coli assessed as breakdown of [14C]-oleamide preincubated for 3 hrs by Dix...				J Med Chem 57: 1079-89 (2014) Article DOI: 10.1021/jm401820q BindingDB Entry DOI: 10.7270/Q2HX1F5K
The Scripps Research Institute Curated by ChEMBL					More data for this Ligand-Target Pair
Fatty-acid amide hydrolase 1 (aa 30-579) (Rattus norvegicus (rat))	BDBM50448896 (CHEMBL3125307) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	0.5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
The Scripps Research Institute Curated by ChEMBL					Assay Description Time-dependent inhibition of recombinant rat FAAH expressed in Escherichia coli assessed as breakdown of [14C]-oleamide preincubated for 6 hrs by Dix...				J Med Chem 57: 1079-89 (2014) Article DOI: 10.1021/jm401820q BindingDB Entry DOI: 10.7270/Q2HX1F5K
The Scripps Research Institute Curated by ChEMBL					More data for this Ligand-Target Pair
Fatty-acid amide hydrolase 1 (aa 30-579) (Rattus norvegicus (rat))	BDBM50448896 (CHEMBL3125307) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	0.900	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
The Scripps Research Institute Curated by ChEMBL					Assay Description Time-dependent inhibition of recombinant rat FAAH expressed in Escherichia coli assessed as breakdown of [14C]-oleamide preincubated for 1 hr by Dixo...				J Med Chem 57: 1079-89 (2014) Article DOI: 10.1021/jm401820q BindingDB Entry DOI: 10.7270/Q2HX1F5K
The Scripps Research Institute Curated by ChEMBL					More data for this Ligand-Target Pair
Fatty-acid amide hydrolase 1 (aa 30-579) (Rattus norvegicus (rat))	BDBM50448896 (CHEMBL3125307) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	1.5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
The Scripps Research Institute Curated by ChEMBL					Assay Description Inhibition of recombinant rat FAAH expressed in Escherichia coli assessed as breakdown of [14C]-oleamide by Dixon plot analysis				J Med Chem 57: 1079-89 (2014) Article DOI: 10.1021/jm401820q BindingDB Entry DOI: 10.7270/Q2HX1F5K
The Scripps Research Institute Curated by ChEMBL					More data for this Ligand-Target Pair
KIAA1363 (Mus musculus (mouse))	BDBM50448896 (CHEMBL3125307) Show SMILES Show InChI	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
The Scripps Research Institute Curated by ChEMBL					Assay Description Competitive inhibition of mouse brain membrane KIAA1363 preincubated for 6 hrs followed by FP-rhodamine addition measured after 10 mins by fluorescen...				J Med Chem 57: 1079-89 (2014) Article DOI: 10.1021/jm401820q BindingDB Entry DOI: 10.7270/Q2HX1F5K
The Scripps Research Institute Curated by ChEMBL					More data for this Ligand-Target Pair
Monoglyceride Lipase (MGL) (Mus musculus (mouse))	BDBM50448896 (CHEMBL3125307) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
The Scripps Research Institute Curated by ChEMBL					Assay Description Competitive inhibition of mouse brain membrane MAGL preincubated for 6 hrs followed by FP-rhodamine addition measured after 10 mins by fluorescence s...				J Med Chem 57: 1079-89 (2014) Article DOI: 10.1021/jm401820q BindingDB Entry DOI: 10.7270/Q2HX1F5K
The Scripps Research Institute Curated by ChEMBL					More data for this Ligand-Target Pair
Abhydrolase Domain-Containing Protein 6 (Mus musculus (mouse))	BDBM50448896 (CHEMBL3125307) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	9.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
The Scripps Research Institute Curated by ChEMBL					Assay Description Competitive inhibition of mouse brain membrane ABHD6 preincubated for 6 hrs followed by FP-rhodamine addition measured after 10 mins by fluorescence ...				J Med Chem 57: 1079-89 (2014) Article DOI: 10.1021/jm401820q BindingDB Entry DOI: 10.7270/Q2HX1F5K
The Scripps Research Institute Curated by ChEMBL					More data for this Ligand-Target Pair
Carboxylesterase 1D (Mus musculus)	BDBM50448896 (CHEMBL3125307) Show SMILES Show InChI	KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	200	n/a	n/a	n/a	n/a	n/a	n/a
The Scripps Research Institute Curated by ChEMBL					Assay Description Competitive inhibition of mouse heart membrane TGH preincubated for 6 hrs followed by FP-rhodamine addition measured after 10 mins by fluorescence sc...				J Med Chem 57: 1079-89 (2014) Article DOI: 10.1021/jm401820q BindingDB Entry DOI: 10.7270/Q2HX1F5K
The Scripps Research Institute Curated by ChEMBL					More data for this Ligand-Target Pair