null
SMILES: COc1ccc(cc1)-c1nc(CNC(=O)\C=C\c2cccc(O)c2)cc2c3ccccc3[nH]c12
InChI Key: InChIKey=AYHPBHOMWOJVIC-NTEUORMPSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Topoisomerase I (Bos taurus) | BDBM50450080 (CHEMBL4176420) | UniProtKB/TrEMBL GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 14 | n/a | n/a | n/a | n/a | n/a | n/a |
CSIR-Indian Institute of Chemical Technology Curated by ChEMBL | Assay Description Inhibition of calf thymus topoisomerase 1-mediated relaxation of supercoiled pBR322 DNA measured after 30 mins by agarose gel electrophoresis method | Bioorg Med Chem 26: 4916-4929 (2018) Article DOI: 10.1016/j.bmc.2018.08.031 BindingDB Entry DOI: 10.7270/Q2FJ2KBF | |||||||||||
More data for this Ligand-Target Pair |