BDBM50450478 CHEMBL4172027::US10597366, Compound 138
SMILES: CS(=O)(=O)c1ccc(Oc2cc(F)cc(Cl)c2)c(Br)c1
InChI Key: InChIKey=DEHILFOXGDHTTI-UHFFFAOYSA-N
Data: 2 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Endothelial PAS domain-containing protein 1 (Homo sapiens (Human)) | BDBM50450478![]() (CHEMBL4172027 | US10597366, Compound 138) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 4.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Peloton Therapeutics, Inc. US Patent | Assay Description HIF-2a: The total assay volume was about 100 uL in the following configuration: 2 uL compound in 100% DMSO, 88 uL buffer with protein and probe and 1... | US Patent US10597366 (2020) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Endothelial PAS domain-containing protein 1 (Homo sapiens (Human)) | BDBM50450478![]() (CHEMBL4172027 | US10597366, Compound 138) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 4.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Peloton Therapeutics, Inc. Curated by ChEMBL | Assay Description Binding affinity to His-tagged HIF-2alpha PAS-B domain (unknown origin) after 2 hrs by scintillation proximity assay | J Med Chem 61: 9691-9721 (2018) Article DOI: 10.1021/acs.jmedchem.8b01196 BindingDB Entry DOI: 10.7270/Q2H997RJ | |||||||||||
More data for this Ligand-Target Pair |