BDBM50450502 CHEMBL3218112

SMILES: OC1(COc2ccc(C#N)c(F)c2)CCN(CC1)S(=O)(=O)c1ccc(Cl)cc1Cl

InChI Key: InChIKey=RHZOBQUFIPYJNS-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50450502   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Transient receptor potential cation channel subfamily V member 4 (Homo sapiens (Human))	BDBM50450502 (CHEMBL3218112) Show SMILES OC1(COc2ccc(C#N)c(F)c2)CCN(CC1)S(=O)(=O)c1ccc(Cl)cc1Cl Show InChI InChI=1S/C19H17Cl2FN2O4S/c20-14-2-4-18(16(21)9-14)29(26,27)24-7-5-19(25,6-8-24)12-28-15-3-1-13(11-23)17(22)10-15/h1-4,9-10,25H,5-8,12H2	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	130	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Antagonist activity at human TRPV4 expressed in BHK/AC9 or HEK MSR2 cells assessed as inhibition of PF-04674114-induced Ca2+ flux pre-incubated for 1...				J Med Chem 61: 9738-9755 (2018) Article DOI: 10.1021/acs.jmedchem.8b01317 BindingDB Entry DOI: 10.7270/Q2CJ8H2P
					More data for this Ligand-Target Pair