BDBM50450504 CHEMBL4167189

SMILES: Fc1cc(OCC2CCN(CC2)S(=O)(=O)c2ccc(Cl)cc2Cl)ccc1C#N

InChI Key: InChIKey=WBVMLXQDGXRNOV-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50450504   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Transient receptor potential cation channel subfamily V member 4 (Homo sapiens (Human))	BDBM50450504 (CHEMBL4167189) Show SMILES Fc1cc(OCC2CCN(CC2)S(=O)(=O)c2ccc(Cl)cc2Cl)ccc1C#N Show InChI InChI=1S/C19H17Cl2FN2O3S/c20-15-2-4-19(17(21)9-15)28(25,26)24-7-5-13(6-8-24)12-27-16-3-1-14(11-23)18(22)10-16/h1-4,9-10,13H,5-8,12H2	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	6.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Antagonist activity at human TRPV4 expressed in BHK/AC9 or HEK MSR2 cells assessed as inhibition of PF-04674114-induced Ca2+ flux pre-incubated for 1...				J Med Chem 61: 9738-9755 (2018) Article DOI: 10.1021/acs.jmedchem.8b01317 BindingDB Entry DOI: 10.7270/Q2CJ8H2P
					More data for this Ligand-Target Pair