BDBM50450506 CHEMBL4165633

SMILES: O[C@@H]1CN(C[C@@H]1COc1ccc(C#N)c(F)c1)S(=O)(=O)c1ccc(Cl)cc1Cl

InChI Key: InChIKey=BXJNNQDYLWMHBF-SJKOYZFVSA-N

Data: 1 IC50

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50450506   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Transient receptor potential cation channel subfamily V member 4 (Homo sapiens (Human))	BDBM50450506 (CHEMBL4165633) Show SMILES O[C@@H]1CN(C[C@@H]1COc1ccc(C#N)c(F)c1)S(=O)(=O)c1ccc(Cl)cc1Cl |r| Show InChI InChI=1S/C18H15Cl2FN2O4S/c19-13-2-4-18(15(20)5-13)28(25,26)23-8-12(17(24)9-23)10-27-14-3-1-11(7-22)16(21)6-14/h1-6,12,17,24H,8-10H2/t12-,17-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Antagonist activity at human TRPV4 expressed in BHK/AC9 or HEK MSR2 cells assessed as inhibition of PF-04674114-induced Ca2+ flux pre-incubated for 1...				J Med Chem 61: 9738-9755 (2018) Article DOI: 10.1021/acs.jmedchem.8b01317 BindingDB Entry DOI: 10.7270/Q2CJ8H2P
					More data for this Ligand-Target Pair