BDBM50451455 CHEMBL2325325

SMILES: NCc1cccc(c1)-c1cc(Cl)ccc1Oc1ccc(cc1C#N)S(=O)(=O)Nc1ncns1

InChI Key: InChIKey=IKXKISRGWFQXCA-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50451455   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM50451455 (CHEMBL2325325) Show SMILES NCc1cccc(c1)-c1cc(Cl)ccc1Oc1ccc(cc1C#N)S(=O)(=O)Nc1ncns1 Show InChI InChI=1S/C22H16ClN5O3S2/c23-17-4-6-21(19(10-17)15-3-1-2-14(8-15)11-24)31-20-7-5-18(9-16(20)12-25)33(29,30)28-22-26-13-27-32-22/h1-10,13H,11,24H2,(H,26,27,28)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	8.40	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Inhibition of NaV1.7 ion channel (unknown origin)				Bioorg Med Chem Lett 23: 261-3 (2013) Article DOI: 10.1016/j.bmcl.2012.10.102 BindingDB Entry DOI: 10.7270/Q2445QD6
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM50451455 (CHEMBL2325325) Show SMILES NCc1cccc(c1)-c1cc(Cl)ccc1Oc1ccc(cc1C#N)S(=O)(=O)Nc1ncns1 Show InChI InChI=1S/C22H16ClN5O3S2/c23-17-4-6-21(19(10-17)15-3-1-2-14(8-15)11-24)31-20-7-5-18(9-16(20)12-25)33(29,30)28-22-26-13-27-32-22/h1-10,13H,11,24H2,(H,26,27,28)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	8.5	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of human Nav1.7 expressed in HEK cells by automated patchXpress electrophysiology method				Bioorg Med Chem Lett 27: 4805-4811 (2017) Article DOI: 10.1016/j.bmcl.2017.09.056 BindingDB Entry DOI: 10.7270/Q25Q4ZN1
					More data for this Ligand-Target Pair