null

SMILES: FC(F)(F)c1ccc2nc3O[C@@]4(Cn3c2c1)CN1CCC4CC1

InChI Key: InChIKey=VELKUFJRZQSDQI-OAHLLOKOSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50451615   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
5-hydroxytryptamine receptor 3A (Homo sapiens (Human))	BDBM50451615 (CHEMBL4203125) Show SMILES FC(F)(F)c1ccc2nc3O[C@@]4(Cn3c2c1)CN1CCC4CC1 |r,wU:11.10,THB:10:11:18.19:22.21,(23.72,-22.53,;22.33,-23.35,;23.73,-24.15,;21.92,-24.92,;21.18,-22.21,;21.57,-20.72,;20.47,-19.64,;18.99,-20.05,;17.7,-19.21,;16.51,-20.19,;14.98,-20.27,;14.59,-21.76,;15.87,-22.59,;17.07,-21.62,;18.6,-21.53,;19.7,-22.62,;14.89,-23.22,;13.45,-22.56,;11.84,-23.25,;11.62,-21.8,;13.17,-21.12,;13.24,-19.4,;13.72,-20.57,)| Show InChI InChI=1S/C16H16F3N3O/c17-16(18,19)11-1-2-12-13(7-11)22-9-15(23-14(22)20-12)8-21-5-3-10(15)4-6-21/h1-2,7,10H,3-6,8-9H2/t15-/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	17	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Antagonist activity at human 5-HT3A receptor expressed in HEK293 cells assessed as inhibition of 5-HT-induced calcium flux preincubated for 30 mins p...				Bioorg Med Chem Lett 27: 5002-5005 (2017) Article DOI: 10.1016/j.bmcl.2017.10.009 BindingDB Entry DOI: 10.7270/Q24Q7XJ3
					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7 (Rattus norvegicus (Rat))	BDBM50451615 (CHEMBL4203125) Show SMILES FC(F)(F)c1ccc2nc3O[C@@]4(Cn3c2c1)CN1CCC4CC1 |r,wU:11.10,THB:10:11:18.19:22.21,(23.72,-22.53,;22.33,-23.35,;23.73,-24.15,;21.92,-24.92,;21.18,-22.21,;21.57,-20.72,;20.47,-19.64,;18.99,-20.05,;17.7,-19.21,;16.51,-20.19,;14.98,-20.27,;14.59,-21.76,;15.87,-22.59,;17.07,-21.62,;18.6,-21.53,;19.7,-22.62,;14.89,-23.22,;13.45,-22.56,;11.84,-23.25,;11.62,-21.8,;13.17,-21.12,;13.24,-19.4,;13.72,-20.57,)| Show InChI InChI=1S/C16H16F3N3O/c17-16(18,19)11-1-2-12-13(7-11)22-9-15(23-14(22)20-12)8-21-5-3-10(15)4-6-21/h1-2,7,10H,3-6,8-9H2/t15-/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	69	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Agonist activity at rat alpha7 nAChR expressed in HEK293 cells co-expressing human RIC-3 assessed as increase in calcium flux measured for 2 mins by ...				Bioorg Med Chem Lett 27: 5002-5005 (2017) Article DOI: 10.1016/j.bmcl.2017.10.009 BindingDB Entry DOI: 10.7270/Q24Q7XJ3
					More data for this Ligand-Target Pair