BDBM50452246 CHEMBL4216687
SMILES: COc1c(F)cc(Cn2ccc(NC(=O)Cc3ccc(cc3)N(C)C)n2)cc1F
InChI Key: InChIKey=QVLLKIOUTFTWMC-UHFFFAOYSA-N
Data: 3 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Voltage-dependent T-type calcium channel subunit alpha-1H (Homo sapiens (Human)) | BDBM50452246 (CHEMBL4216687) | UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 7.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Idorsia Pharmaceuticals Ltd. Curated by ChEMBL | Assay Description Inhibition of recombinant Cav3.2 (unknown origin) expressed in HEK293 cells assessed as decrease in calcium flux preincubated for 3 mins followed by ... | J Med Chem 60: 9769-9789 (2017) Article DOI: 10.1021/acs.jmedchem.7b01236 BindingDB Entry DOI: 10.7270/Q24M9745 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Voltage-gated T-type calcium channel (Homo sapiens (Human)) | BDBM50452246 (CHEMBL4216687) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 3.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Idorsia Pharmaceuticals Ltd. Curated by ChEMBL | Assay Description Inhibition of recombinant Cav3.1 (unknown origin) expressed in HEK293 cells assessed as decrease in calcium flux preincubated for 3 mins followed by ... | J Med Chem 60: 9769-9789 (2017) Article DOI: 10.1021/acs.jmedchem.7b01236 BindingDB Entry DOI: 10.7270/Q24M9745 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Voltage-gated T-type calcium channel (Homo sapiens (Human)) | BDBM50452246 (CHEMBL4216687) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 0.920 | n/a | n/a | n/a | n/a | n/a | n/a |
Idorsia Pharmaceuticals Ltd. Curated by ChEMBL | Assay Description Inhibition of recombinant Cav3.3 (unknown origin) expressed in HEK293 cells assessed as decrease in calcium flux preincubated for 3 mins followed by ... | J Med Chem 60: 9769-9789 (2017) Article DOI: 10.1021/acs.jmedchem.7b01236 BindingDB Entry DOI: 10.7270/Q24M9745 | |||||||||||
More data for this Ligand-Target Pair |