BDBM50452289 CHEMBL4215974

SMILES: CC1(COC1)c1ccc(CC(=O)Nc2ccn(Cc3ccc(F)c(F)c3)n2)cc1

InChI Key: InChIKey=VYABCIPHYKWXBF-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50452289   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Voltage-gated T-type calcium channel (Homo sapiens (Human))	BDBM50452289 (CHEMBL4215974) Show SMILES CC1(COC1)c1ccc(CC(=O)Nc2ccn(Cc3ccc(F)c(F)c3)n2)cc1 Show InChI InChI=1S/C22H21F2N3O2/c1-22(13-29-14-22)17-5-2-15(3-6-17)11-21(28)25-20-8-9-27(26-20)12-16-4-7-18(23)19(24)10-16/h2-10H,11-14H2,1H3,(H,25,26,28)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.20	n/a	n/a	n/a	n/a	n/a	n/a
Idorsia Pharmaceuticals Ltd. Curated by ChEMBL					Assay Description Inhibition of recombinant Cav3.3 (unknown origin) expressed in HEK293 cells assessed as decrease in calcium flux preincubated for 3 mins followed by ...				J Med Chem 60: 9769-9789 (2017) Article DOI: 10.1021/acs.jmedchem.7b01236 BindingDB Entry DOI: 10.7270/Q24M9745
					More data for this Ligand-Target Pair
Voltage-gated T-type calcium channel (Homo sapiens (Human))	BDBM50452289 (CHEMBL4215974) Show SMILES CC1(COC1)c1ccc(CC(=O)Nc2ccn(Cc3ccc(F)c(F)c3)n2)cc1 Show InChI InChI=1S/C22H21F2N3O2/c1-22(13-29-14-22)17-5-2-15(3-6-17)11-21(28)25-20-8-9-27(26-20)12-16-4-7-18(23)19(24)10-16/h2-10H,11-14H2,1H3,(H,25,26,28)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.40	n/a	n/a	n/a	n/a	n/a	n/a
Idorsia Pharmaceuticals Ltd. Curated by ChEMBL					Assay Description Inhibition of recombinant Cav3.1 (unknown origin) expressed in HEK293 cells assessed as decrease in calcium flux preincubated for 3 mins followed by ...				J Med Chem 60: 9769-9789 (2017) Article DOI: 10.1021/acs.jmedchem.7b01236 BindingDB Entry DOI: 10.7270/Q24M9745
					More data for this Ligand-Target Pair
Voltage-dependent T-type calcium channel subunit alpha-1H (Homo sapiens (Human))	BDBM50452289 (CHEMBL4215974) Show SMILES CC1(COC1)c1ccc(CC(=O)Nc2ccn(Cc3ccc(F)c(F)c3)n2)cc1 Show InChI InChI=1S/C22H21F2N3O2/c1-22(13-29-14-22)17-5-2-15(3-6-17)11-21(28)25-20-8-9-27(26-20)12-16-4-7-18(23)19(24)10-16/h2-10H,11-14H2,1H3,(H,25,26,28)	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	4.30	n/a	n/a	n/a	n/a	n/a	n/a
Idorsia Pharmaceuticals Ltd. Curated by ChEMBL					Assay Description Inhibition of recombinant Cav3.2 (unknown origin) expressed in HEK293 cells assessed as decrease in calcium flux preincubated for 3 mins followed by ...				J Med Chem 60: 9769-9789 (2017) Article DOI: 10.1021/acs.jmedchem.7b01236 BindingDB Entry DOI: 10.7270/Q24M9745
					More data for this Ligand-Target Pair