null

SMILES: CC(=O)Nc1cc(Nc2nc(nc3[nH]cnc23)-c2cccc(n2)C(F)(F)F)ccn1

InChI Key: InChIKey=GJWRNXGORZZUIM-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50454872   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
TGF-beta receptor type-1 (Homo sapiens (Human))	BDBM50454872 (CHEMBL4205456) Show SMILES CC(=O)Nc1cc(Nc2nc(nc3[nH]cnc23)-c2cccc(n2)C(F)(F)F)ccn1 Show InChI InChI=1S/C18H13F3N8O/c1-9(30)25-13-7-10(5-6-22-13)26-17-14-16(24-8-23-14)28-15(29-17)11-3-2-4-12(27-11)18(19,20)21/h2-8H,1H3,(H3,22,23,24,25,26,28,29,30)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.10	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company Curated by ChEMBL					Assay Description Inhibition of human His-tagged TGFbetaR1 T204D mutant expressed in Sf9 insect cells after 1 hr by HTRF assay				Bioorg Med Chem 26: 1026-1034 (2018) Article DOI: 10.1016/j.bmc.2018.01.014 BindingDB Entry DOI: 10.7270/Q27M0BHV
					More data for this Ligand-Target Pair
TGF-beta receptor type-1 (Homo sapiens (Human))	BDBM50454872 (CHEMBL4205456) Show SMILES CC(=O)Nc1cc(Nc2nc(nc3[nH]cnc23)-c2cccc(n2)C(F)(F)F)ccn1 Show InChI InChI=1S/C18H13F3N8O/c1-9(30)25-13-7-10(5-6-22-13)26-17-14-16(24-8-23-14)28-15(29-17)11-3-2-4-12(27-11)18(19,20)21/h2-8H,1H3,(H3,22,23,24,25,26,28,29,30)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	50	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company Curated by ChEMBL					Assay Description Inhibition of TGFbetaR1 in human primary T-cells assessed as TGFbeta-stimulated PSMAD phosphorylation preincubated for 1 hr followed by TGFbeta addit...				Bioorg Med Chem 26: 1026-1034 (2018) Article DOI: 10.1016/j.bmc.2018.01.014 BindingDB Entry DOI: 10.7270/Q27M0BHV
					More data for this Ligand-Target Pair