BDBM50455949 CHEMBL4211724
SMILES: [H][C@]12CN(Cc3ccc(cc3)C(F)(F)F)C[C@@]1(C(=O)CO)[C@@]1(C)C[C@H](O)[C@@]3(F)[C@@]([H])(C[C@H](F)C4=CC(=O)C=C[C@]34C)[C@]1([H])C2
InChI Key: InChIKey=CBWZKVLJHYHQTQ-FCQBLWMMSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Glucocorticoid receptor (Homo sapiens (Human)) | BDBM50455949 (CHEMBL4211724) | PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 0.660 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Displacement of [3H]dexamethasone from human recombinant glucocorticoid receptor expressed in insect cells after 24 hrs by scintillation proximity as... | J Med Chem 61: 4757-4773 (2018) Article DOI: 10.1021/acs.jmedchem.7b01873 BindingDB Entry DOI: 10.7270/Q2JS9T19 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mineralocorticoid receptor (Homo sapiens (Human)) | BDBM50455949 (CHEMBL4211724) | PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 3.20 | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Induction of nuclear translocation of human recombinant ProLabel-tagged mineralocorticoid receptor expressed in CHO-K1 cells after 3 hrs by luminesce... | J Med Chem 61: 4757-4773 (2018) Article DOI: 10.1021/acs.jmedchem.7b01873 BindingDB Entry DOI: 10.7270/Q2JS9T19 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glucocorticoid receptor (Homo sapiens (Human)) | BDBM50455949 (CHEMBL4211724) | PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 5.30 | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Induction of nuclear translocation of human recombinant ProLabel-tagged glucocorticoid receptor expressed in CHO-K1 cells after 3 hrs by luminescence... | J Med Chem 61: 4757-4773 (2018) Article DOI: 10.1021/acs.jmedchem.7b01873 BindingDB Entry DOI: 10.7270/Q2JS9T19 | |||||||||||
More data for this Ligand-Target Pair |