Found 4 hits for monomerid = 50456925 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kcal/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
p110α/p85α
(Homo sapiens (Human)) | BDBM50456925
(CHEMBL4207150)Show SMILES COc1ncc(cc1NS(=O)(=O)c1ccc(F)cc1F)-c1ccc2ncn(CCCN3CCOCC3)c(=O)c2c1 Show InChI InChI=1S/C27H27F2N5O5S/c1-38-26-24(32-40(36,37)25-6-4-20(28)15-22(25)29)14-19(16-30-26)18-3-5-23-21(13-18)27(35)34(17-31-23)8-2-7-33-9-11-39-12-10-33/h3-6,13-17,32H,2,7-12H2,1H3 | PDB
UniProtKB/SwissProt
UniProtKB/TrEMBL
antibodypedia
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 6.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Shenyang Pharmaceutical University
Curated by ChEMBL
| Assay Description
Inhibition of N-terminal His6-tagged recombinant full-length human p110alpha/untagged recombinant full length human p85alpha expressed in baculovirus... |
Eur J Med Chem 139: 95-106 (2017)
Article DOI: 10.1016/j.ejmech.2017.07.074
BindingDB Entry DOI: 10.7270/Q2KH0QXV |
More data for this
Ligand-Target Pair | |
Phosphoinositide 3-Kinase (PI3K), delta
(Homo sapiens (Human)) | BDBM50456925
(CHEMBL4207150)Show SMILES COc1ncc(cc1NS(=O)(=O)c1ccc(F)cc1F)-c1ccc2ncn(CCCN3CCOCC3)c(=O)c2c1 Show InChI InChI=1S/C27H27F2N5O5S/c1-38-26-24(32-40(36,37)25-6-4-20(28)15-22(25)29)14-19(16-30-26)18-3-5-23-21(13-18)27(35)34(17-31-23)8-2-7-33-9-11-39-12-10-33/h3-6,13-17,32H,2,7-12H2,1H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
UniProtKB/TrEMBL
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 69 | n/a | n/a | n/a | n/a | n/a | n/a |
Shenyang Pharmaceutical University
Curated by ChEMBL
| Assay Description
Inhibition of p110delta/p85alpha (unknown origin) using PIP2 as substrate by HTRF colorimetric assay |
Eur J Med Chem 139: 95-106 (2017)
Article DOI: 10.1016/j.ejmech.2017.07.074
BindingDB Entry DOI: 10.7270/Q2KH0QXV |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
(Homo sapiens (Human)) | BDBM50456925
(CHEMBL4207150)Show SMILES COc1ncc(cc1NS(=O)(=O)c1ccc(F)cc1F)-c1ccc2ncn(CCCN3CCOCC3)c(=O)c2c1 Show InChI InChI=1S/C27H27F2N5O5S/c1-38-26-24(32-40(36,37)25-6-4-20(28)15-22(25)29)14-19(16-30-26)18-3-5-23-21(13-18)27(35)34(17-31-23)8-2-7-33-9-11-39-12-10-33/h3-6,13-17,32H,2,7-12H2,1H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
UniProtKB/TrEMBL
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 116 | n/a | n/a | n/a | n/a | n/a | n/a |
Shenyang Pharmaceutical University
Curated by ChEMBL
| Assay Description
Inhibition of N-terminal His6-tagged recombinant full-length human PI3Kgamma expressed in baculovirus infected Sf21 insect cells using PIP2 as substr... |
Eur J Med Chem 139: 95-106 (2017)
Article DOI: 10.1016/j.ejmech.2017.07.074
BindingDB Entry DOI: 10.7270/Q2KH0QXV |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
(Homo sapiens (Human)) | BDBM50456925
(CHEMBL4207150)Show SMILES COc1ncc(cc1NS(=O)(=O)c1ccc(F)cc1F)-c1ccc2ncn(CCCN3CCOCC3)c(=O)c2c1 Show InChI InChI=1S/C27H27F2N5O5S/c1-38-26-24(32-40(36,37)25-6-4-20(28)15-22(25)29)14-19(16-30-26)18-3-5-23-21(13-18)27(35)34(17-31-23)8-2-7-33-9-11-39-12-10-33/h3-6,13-17,32H,2,7-12H2,1H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 108 | n/a | n/a | n/a | n/a | n/a | n/a |
Shenyang Pharmaceutical University
Curated by ChEMBL
| Assay Description
Inhibition of PI3Kbeta (unknown origin) using PIP2 as substrate by HTRF colorimetric assay |
Eur J Med Chem 139: 95-106 (2017)
Article DOI: 10.1016/j.ejmech.2017.07.074
BindingDB Entry DOI: 10.7270/Q2KH0QXV |
More data for this
Ligand-Target Pair | |
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