null

SMILES: C[C@H](NC(=O)C(C)(F)F)[C@H](Oc1ccc2n(ncc2c1)-c1ccc(=O)n(CC2CC2)c1)c1ccccc1

InChI Key: InChIKey=KARDSHKKBLFUKZ-QYBDOPJKSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50457415   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Glucocorticoid receptor (Homo sapiens (Human))	BDBM50457415 (CHEMBL4202668) Show SMILES C[C@H](NC(=O)C(C)(F)F)[C@H](Oc1ccc2n(ncc2c1)-c1ccc(=O)n(CC2CC2)c1)c1ccccc1 |r| Show InChI InChI=1S/C28H28F2N4O3/c1-18(32-27(36)28(2,29)30)26(20-6-4-3-5-7-20)37-23-11-12-24-21(14-23)15-31-34(24)22-10-13-25(35)33(17-22)16-19-8-9-19/h3-7,10-15,17-19,26H,8-9,16H2,1-2H3,(H,32,36)/t18-,26-/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	226	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Transrepression activity at glucocorticoid receptor (unknown origin) expressed in human ChaGoK1 cells assessed as inhibition of PMA-stimulated gene e...				J Med Chem 61: 1785-1799 (2018) Article DOI: 10.1021/acs.jmedchem.7b01690 BindingDB Entry DOI: 10.7270/Q2XK8J5R
					More data for this Ligand-Target Pair
Glucocorticoid receptor (Homo sapiens (Human))	BDBM50457415 (CHEMBL4202668) Show SMILES C[C@H](NC(=O)C(C)(F)F)[C@H](Oc1ccc2n(ncc2c1)-c1ccc(=O)n(CC2CC2)c1)c1ccccc1 |r| Show InChI InChI=1S/C28H28F2N4O3/c1-18(32-27(36)28(2,29)30)26(20-6-4-3-5-7-20)37-23-11-12-24-21(14-23)15-31-34(24)22-10-13-25(35)33(17-22)16-19-8-9-19/h3-7,10-15,17-19,26H,8-9,16H2,1-2H3,(H,32,36)/t18-,26-/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	449	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Antagonist activity at glucocorticoid receptor (unknown origin) expressed in human ChaGoK1 cells assessed as inhibition of dexamethasone induced tran...				J Med Chem 61: 1785-1799 (2018) Article DOI: 10.1021/acs.jmedchem.7b01690 BindingDB Entry DOI: 10.7270/Q2XK8J5R
					More data for this Ligand-Target Pair
Glucocorticoid receptor (Homo sapiens (Human))	BDBM50457415 (CHEMBL4202668) Show SMILES C[C@H](NC(=O)C(C)(F)F)[C@H](Oc1ccc2n(ncc2c1)-c1ccc(=O)n(CC2CC2)c1)c1ccccc1 |r| Show InChI InChI=1S/C28H28F2N4O3/c1-18(32-27(36)28(2,29)30)26(20-6-4-3-5-7-20)37-23-11-12-24-21(14-23)15-31-34(24)22-10-13-25(35)33(17-22)16-19-8-9-19/h3-7,10-15,17-19,26H,8-9,16H2,1-2H3,(H,32,36)/t18-,26-/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	4.40	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Displacement of fluormone RED from human full length glucocorticoid receptor after 4 hrs by fluorescence polarization assay				J Med Chem 61: 1785-1799 (2018) Article DOI: 10.1021/acs.jmedchem.7b01690 BindingDB Entry DOI: 10.7270/Q2XK8J5R
					More data for this Ligand-Target Pair