null

SMILES: COc1ccc(\C=N\NC(=O)CCCn2c(NCc3ccccc3)nc3n(C)c(=O)n(C)c(=O)c23)c(O)c1

InChI Key: InChIKey=VIWWFFQWMHWPCF-LQKURTRISA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50457950   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A (Homo sapiens (Human))	BDBM50457950 (CHEMBL4217007) Show SMILES COc1ccc(\C=N\NC(=O)CCCn2c(NCc3ccccc3)nc3n(C)c(=O)n(C)c(=O)c23)c(O)c1 Show InChI InChI=1S/C26H29N7O5/c1-31-23-22(24(36)32(2)26(31)37)33(25(29-23)27-15-17-8-5-4-6-9-17)13-7-10-21(35)30-28-16-18-11-12-19(38-3)14-20(18)34/h4-6,8-9,11-12,14,16,34H,7,10,13,15H2,1-3H3,(H,27,29)(H,30,35)/b28-16+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	5.28E+4	n/a	n/a	n/a	n/a	n/a	n/a
Jagiellonian University Curated by ChEMBL					Assay Description Inhibition of human GST-tagged PDE7A expressed in baculovirus infected Sf9 insect cells using cAMP as substrate after 10 mins by PDE-Glo Phosphodiest...				Eur J Med Chem 146: 381-394 (2018) Article DOI: 10.1016/j.ejmech.2018.01.068 BindingDB Entry DOI: 10.7270/Q2XD1496
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM50457950 (CHEMBL4217007) Show SMILES COc1ccc(\C=N\NC(=O)CCCn2c(NCc3ccccc3)nc3n(C)c(=O)n(C)c(=O)c23)c(O)c1 Show InChI InChI=1S/C26H29N7O5/c1-31-23-22(24(36)32(2)26(31)37)33(25(29-23)27-15-17-8-5-4-6-9-17)13-7-10-21(35)30-28-16-18-11-12-19(38-3)14-20(18)34/h4-6,8-9,11-12,14,16,34H,7,10,13,15H2,1-3H3,(H,27,29)(H,30,35)/b28-16+	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	4.40E+4	n/a	n/a	n/a	n/a	n/a	n/a
Jagiellonian University Curated by ChEMBL					Assay Description Inhibition of human GST-tagged PDE4B expressed in baculovirus infected Sf9 insect cells using cAMP as substrate after 10 mins by PDE-Glo Phosphodiest...				Eur J Med Chem 146: 381-394 (2018) Article DOI: 10.1016/j.ejmech.2018.01.068 BindingDB Entry DOI: 10.7270/Q2XD1496
					More data for this Ligand-Target Pair