Found 3 hits for monomerid = 50458626 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Proto-oncogene tyrosine-protein kinase receptor Ret
(Homo sapiens (Human)) | BDBM50458626
(CHEMBL4214146)Show SMILES CCOc1cc(=O)[nH]cc1-c1ccc(CC(=O)Nc2ccc(C(C)C#N)c(c2)C(F)(F)F)c(F)c1 Show InChI InChI=1S/C25H21F4N3O3/c1-3-35-22-11-23(33)31-13-19(22)15-4-5-16(21(26)8-15)9-24(34)32-17-6-7-18(14(2)12-30)20(10-17)25(27,28)29/h4-8,10-11,13-14H,3,9H2,1-2H3,(H,31,33)(H,32,34) | PDB MMDB
KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 0.700 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description Inhibition of human RET using cisbio TK biotin-peptide as substrate preincubated for 30 mins followed by substrate addition measured after 1 hr by HT... |
ACS Med Chem Lett 9: 623-628 (2018)
Article DOI: 10.1021/acsmedchemlett.8b00035 BindingDB Entry DOI: 10.7270/Q2TB19GW |
More data for this Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase receptor Ret
(Homo sapiens (Human)) | BDBM50458626
(CHEMBL4214146)Show SMILES CCOc1cc(=O)[nH]cc1-c1ccc(CC(=O)Nc2ccc(C(C)C#N)c(c2)C(F)(F)F)c(F)c1 Show InChI InChI=1S/C25H21F4N3O3/c1-3-35-22-11-23(33)31-13-19(22)15-4-5-16(21(26)8-15)9-24(34)32-17-6-7-18(14(2)12-30)20(10-17)25(27,28)29/h4-8,10-11,13-14H,3,9H2,1-2H3,(H,31,33)(H,32,34) | PDB MMDB
KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 63 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description Inhibition of RET phosphorylation in human TT cells after 2 hrs by ELISA |
ACS Med Chem Lett 9: 623-628 (2018)
Article DOI: 10.1021/acsmedchemlett.8b00035 BindingDB Entry DOI: 10.7270/Q2TB19GW |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50458626
(CHEMBL4214146)Show SMILES CCOc1cc(=O)[nH]cc1-c1ccc(CC(=O)Nc2ccc(C(C)C#N)c(c2)C(F)(F)F)c(F)c1 Show InChI InChI=1S/C25H21F4N3O3/c1-3-35-22-11-23(33)31-13-19(22)15-4-5-16(21(26)8-15)9-24(34)32-17-6-7-18(14(2)12-30)20(10-17)25(27,28)29/h4-8,10-11,13-14H,3,9H2,1-2H3,(H,31,33)(H,32,34) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 92 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description Inhibition of human KDR using cisbio TK biotin-peptide as substrate preincubated for 30 mins followed by substrate addition measured after 30 mins by... |
ACS Med Chem Lett 9: 623-628 (2018)
Article DOI: 10.1021/acsmedchemlett.8b00035 BindingDB Entry DOI: 10.7270/Q2TB19GW |
More data for this Ligand-Target Pair | |