BDBM50460824 CHEMBL4063514

SMILES: CCCN1CCC(CC1)N(Cc1cc(F)cc(c1)C(F)(F)F)C(=O)Nc1cccc(c1)C(F)(F)F

InChI Key: InChIKey=IEHVAXVEGOKCRG-UHFFFAOYSA-N

Data: 1 IC50  1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50460824   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
DCN1-like protein 1 (Homo sapiens)	BDBM50460824 (CHEMBL4063514 | US11116757, No. A68) Show SMILES CCCN1CCC(CC1)N(Cc1cc(F)cc(c1)C(F)(F)F)C(=O)Nc1cccc(c1)C(F)(F)F Show InChI InChI=1S/C24H26F7N3O/c1-2-8-33-9-6-21(7-10-33)34(15-16-11-18(24(29,30)31)13-19(25)12-16)22(35)32-20-5-3-4-17(14-20)23(26,27)28/h3-5,11-14,21H,2,6-10,15H2,1H3,(H,32,35)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
St. Jude Children's Research Hospital Curated by ChEMBL					Assay Description Binding affinity biotinylated human GST-tagged DCN1 assessed as inhibition of protein interaction with AlexaFluor 488-tagged and N-terminally acetyla...				J Med Chem 61: 2680-2693 (2018) Article DOI: 10.1021/acs.jmedchem.7b01277 BindingDB Entry DOI: 10.7270/Q29K4DVZ
					More data for this Ligand-Target Pair
DCN1-like protein 1 (Homo sapiens)	BDBM50460824 (CHEMBL4063514 | US11116757, No. A68) Show SMILES CCCN1CCC(CC1)N(Cc1cc(F)cc(c1)C(F)(F)F)C(=O)Nc1cccc(c1)C(F)(F)F Show InChI InChI=1S/C24H26F7N3O/c1-2-8-33-9-6-21(7-10-33)34(15-16-11-18(24(29,30)31)13-19(25)12-16)22(35)32-20-5-3-4-17(14-20)23(26,27)28/h3-5,11-14,21H,2,6-10,15H2,1H3,(H,32,35)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	180	n/a	n/a	n/a	n/a
St. Jude Children's Research Hospital Curated by ChEMBL					Assay Description Inhibition of human DCN1-mediated cullin neddylation assessed as reduction in transfer of fluorescein-5-maleimide-tagged NEDD8 from N-terminally acet...				J Med Chem 61: 2680-2693 (2018) Article DOI: 10.1021/acs.jmedchem.7b01277 BindingDB Entry DOI: 10.7270/Q29K4DVZ
					More data for this Ligand-Target Pair
DCN1-UBC12 (Homo sapiens)	BDBM50460824 (CHEMBL4063514 | US11116757, No. A68) Show SMILES CCCN1CCC(CC1)N(Cc1cc(F)cc(c1)C(F)(F)F)C(=O)Nc1cccc(c1)C(F)(F)F Show InChI InChI=1S/C24H26F7N3O/c1-2-8-33-9-6-21(7-10-33)34(15-16-11-18(24(29,30)31)13-19(25)12-16)22(35)32-20-5-3-4-17(14-20)23(26,27)28/h3-5,11-14,21H,2,6-10,15H2,1H3,(H,32,35)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	480	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
DCN1-UBC12 (Homo sapiens)	BDBM50460824 (CHEMBL4063514 | US11116757, No. A68) Show SMILES CCCN1CCC(CC1)N(Cc1cc(F)cc(c1)C(F)(F)F)C(=O)Nc1cccc(c1)C(F)(F)F Show InChI InChI=1S/C24H26F7N3O/c1-2-8-33-9-6-21(7-10-33)34(15-16-11-18(24(29,30)31)13-19(25)12-16)22(35)32-20-5-3-4-17(14-20)23(26,27)28/h3-5,11-14,21H,2,6-10,15H2,1H3,(H,32,35)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	480	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
DCN1-UBC12 (Homo sapiens)	BDBM50460824 (CHEMBL4063514 | US11116757, No. A68) Show SMILES CCCN1CCC(CC1)N(Cc1cc(F)cc(c1)C(F)(F)F)C(=O)Nc1cccc(c1)C(F)(F)F Show InChI InChI=1S/C24H26F7N3O/c1-2-8-33-9-6-21(7-10-33)34(15-16-11-18(24(29,30)31)13-19(25)12-16)22(35)32-20-5-3-4-17(14-20)23(26,27)28/h3-5,11-14,21H,2,6-10,15H2,1H3,(H,32,35)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	488	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair