BDBM50461305 CHEMBL4225917

SMILES: CC1=C(C(NC(=O)N1)c1ccc(F)c(CC(=O)N2Cc3ccc(C)cc3C2)c1)C(=O)Nc1ccc2[nH]ncc2c1

InChI Key: InChIKey=DFVNXKBWZZASCC-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50461305   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Rhodopsin kinase (Homo sapiens (Human))	BDBM50461305 (CHEMBL4225917) Show SMILES CC1=C(C(NC(=O)N1)c1ccc(F)c(CC(=O)N2Cc3ccc(C)cc3C2)c1)C(=O)Nc1ccc2[nH]ncc2c1 |t:1| Show InChI InChI=1S/C30H27FN6O3/c1-16-3-4-19-14-37(15-22(19)9-16)26(38)12-20-10-18(5-7-24(20)31)28-27(17(2)33-30(40)35-28)29(39)34-23-6-8-25-21(11-23)13-32-36-25/h3-11,13,28H,12,14-15H2,1-2H3,(H,32,36)(H,34,39)(H2,33,35,40)	NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Michigan Curated by ChEMBL					Assay Description Inhibition of GRK1 (unknown origin) preincubated for 10 mins followed by peptide substrate and ATP addition measured after 1 hr by TR-FRET assay				Bioorg Med Chem Lett 28: 1507-1515 (2018) Article DOI: 10.1016/j.bmcl.2018.03.082 BindingDB Entry DOI: 10.7270/Q22Z1868
					More data for this Ligand-Target Pair
G protein-coupled receptor kinase 5 (Homo sapiens (Human))	BDBM50461305 (CHEMBL4225917) Show SMILES CC1=C(C(NC(=O)N1)c1ccc(F)c(CC(=O)N2Cc3ccc(C)cc3C2)c1)C(=O)Nc1ccc2[nH]ncc2c1 |t:1| Show InChI InChI=1S/C30H27FN6O3/c1-16-3-4-19-14-37(15-22(19)9-16)26(38)12-20-10-18(5-7-24(20)31)28-27(17(2)33-30(40)35-28)29(39)34-23-6-8-25-21(11-23)13-32-36-25/h3-11,13,28H,12,14-15H2,1-2H3,(H,32,36)(H,34,39)(H2,33,35,40)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	6.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Michigan Curated by ChEMBL					Assay Description Inhibition of GRK5 (unknown origin) preincubated for 10 mins followed by peptide substrate and ATP addition measured after 1 hr by TR-FRET assay				Bioorg Med Chem Lett 28: 1507-1515 (2018) Article DOI: 10.1016/j.bmcl.2018.03.082 BindingDB Entry DOI: 10.7270/Q22Z1868
					More data for this Ligand-Target Pair
Beta-adrenergic receptor kinase 1 (Homo sapiens (Human))	BDBM50461305 (CHEMBL4225917) Show SMILES CC1=C(C(NC(=O)N1)c1ccc(F)c(CC(=O)N2Cc3ccc(C)cc3C2)c1)C(=O)Nc1ccc2[nH]ncc2c1 |t:1| Show InChI InChI=1S/C30H27FN6O3/c1-16-3-4-19-14-37(15-22(19)9-16)26(38)12-20-10-18(5-7-24(20)31)28-27(17(2)33-30(40)35-28)29(39)34-23-6-8-25-21(11-23)13-32-36-25/h3-11,13,28H,12,14-15H2,1-2H3,(H,32,36)(H,34,39)(H2,33,35,40)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	200	n/a	n/a	n/a	n/a	n/a	n/a
University of Michigan Curated by ChEMBL					Assay Description Inhibition of GRK2 (unknown origin) preincubated for 10 mins followed by peptide substrate and ATP addition measured after 1 hr by TR-FRET assay				Bioorg Med Chem Lett 28: 1507-1515 (2018) Article DOI: 10.1016/j.bmcl.2018.03.082 BindingDB Entry DOI: 10.7270/Q22Z1868
					More data for this Ligand-Target Pair