BDBM50461315 CHEMBL4225489
SMILES: CCCCN(CC#CC)C(=O)Cc1cc(ccc1F)C1NC(=O)NC(C)=C1C(=O)Nc1ccc2[nH]ncc2c1
InChI Key: InChIKey=CLHDCAUANAHCAY-UHFFFAOYSA-N
Data: 3 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Beta-adrenergic receptor kinase 1 (Homo sapiens (Human)) | BDBM50461315![]() (CHEMBL4225489) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 430 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Michigan Curated by ChEMBL | Assay Description Inhibition of GRK2 (unknown origin) preincubated for 10 mins followed by peptide substrate and ATP addition measured after 1 hr by TR-FRET assay | Bioorg Med Chem Lett 28: 1507-1515 (2018) Article DOI: 10.1016/j.bmcl.2018.03.082 BindingDB Entry DOI: 10.7270/Q22Z1868 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
G protein-coupled receptor kinase 5 (Homo sapiens (Human)) | BDBM50461315![]() (CHEMBL4225489) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 2.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Michigan Curated by ChEMBL | Assay Description Inhibition of GRK5 (unknown origin) preincubated for 10 mins followed by peptide substrate and ATP addition measured after 1 hr by TR-FRET assay | Bioorg Med Chem Lett 28: 1507-1515 (2018) Article DOI: 10.1016/j.bmcl.2018.03.082 BindingDB Entry DOI: 10.7270/Q22Z1868 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Rhodopsin kinase (Homo sapiens (Human)) | BDBM50461315![]() (CHEMBL4225489) | NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | Article PubMed | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Michigan Curated by ChEMBL | Assay Description Inhibition of GRK1 (unknown origin) preincubated for 10 mins followed by peptide substrate and ATP addition measured after 1 hr by TR-FRET assay | Bioorg Med Chem Lett 28: 1507-1515 (2018) Article DOI: 10.1016/j.bmcl.2018.03.082 BindingDB Entry DOI: 10.7270/Q22Z1868 | |||||||||||
More data for this Ligand-Target Pair |