BDBM50461320 CHEMBL4227666

SMILES: Cc1noc(C)c1CCNC(=O)c1cc(ccc1F)C1NC(=O)NC(C)=C1C(=O)Nc1ccc2[nH]ncc2c1

InChI Key: InChIKey=JWFOLANTFTXARN-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50461320   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Beta-adrenergic receptor kinase 1 (Homo sapiens (Human))	BDBM50461320 (CHEMBL4227666) Show SMILES Cc1noc(C)c1CCNC(=O)c1cc(ccc1F)C1NC(=O)NC(C)=C1C(=O)Nc1ccc2[nH]ncc2c1 |c:27| Show InChI InChI=1S/C27H26FN7O4/c1-13-19(15(3)39-35-13)8-9-29-25(36)20-11-16(4-6-21(20)28)24-23(14(2)31-27(38)33-24)26(37)32-18-5-7-22-17(10-18)12-30-34-22/h4-7,10-12,24H,8-9H2,1-3H3,(H,29,36)(H,30,34)(H,32,37)(H2,31,33,38)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	640	n/a	n/a	n/a	n/a	n/a	n/a
University of Michigan Curated by ChEMBL					Assay Description Inhibition of GRK2 (unknown origin) preincubated for 10 mins followed by peptide substrate and ATP addition measured after 1 hr by TR-FRET assay				Bioorg Med Chem Lett 28: 1507-1515 (2018) Article DOI: 10.1016/j.bmcl.2018.03.082 BindingDB Entry DOI: 10.7270/Q22Z1868
					More data for this Ligand-Target Pair
G protein-coupled receptor kinase 5 (Homo sapiens (Human))	BDBM50461320 (CHEMBL4227666) Show SMILES Cc1noc(C)c1CCNC(=O)c1cc(ccc1F)C1NC(=O)NC(C)=C1C(=O)Nc1ccc2[nH]ncc2c1 |c:27| Show InChI InChI=1S/C27H26FN7O4/c1-13-19(15(3)39-35-13)8-9-29-25(36)20-11-16(4-6-21(20)28)24-23(14(2)31-27(38)33-24)26(37)32-18-5-7-22-17(10-18)12-30-34-22/h4-7,10-12,24H,8-9H2,1-3H3,(H,29,36)(H,30,34)(H,32,37)(H2,31,33,38)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.80E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Michigan Curated by ChEMBL					Assay Description Inhibition of GRK5 (unknown origin) preincubated for 10 mins followed by peptide substrate and ATP addition measured after 1 hr by TR-FRET assay				Bioorg Med Chem Lett 28: 1507-1515 (2018) Article DOI: 10.1016/j.bmcl.2018.03.082 BindingDB Entry DOI: 10.7270/Q22Z1868
					More data for this Ligand-Target Pair
Rhodopsin kinase (Homo sapiens (Human))	BDBM50461320 (CHEMBL4227666) Show SMILES Cc1noc(C)c1CCNC(=O)c1cc(ccc1F)C1NC(=O)NC(C)=C1C(=O)Nc1ccc2[nH]ncc2c1 |c:27| Show InChI InChI=1S/C27H26FN7O4/c1-13-19(15(3)39-35-13)8-9-29-25(36)20-11-16(4-6-21(20)28)24-23(14(2)31-27(38)33-24)26(37)32-18-5-7-22-17(10-18)12-30-34-22/h4-7,10-12,24H,8-9H2,1-3H3,(H,29,36)(H,30,34)(H,32,37)(H2,31,33,38)	NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Michigan Curated by ChEMBL					Assay Description Inhibition of GRK1 (unknown origin) preincubated for 10 mins followed by peptide substrate and ATP addition measured after 1 hr by TR-FRET assay				Bioorg Med Chem Lett 28: 1507-1515 (2018) Article DOI: 10.1016/j.bmcl.2018.03.082 BindingDB Entry DOI: 10.7270/Q22Z1868
					More data for this Ligand-Target Pair