Found 5 hits for monomerid = 50462185 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Breakpoint cluster region protein/Tyrosine-protein kinase ABL1
(Homo sapiens (Human)) | BDBM50462185
![PNG](/data/jpeg/tenK5046/BindingDB_50462185.png) (CHEMBL4237900)Show SMILES CC(C)n1nc(C#Cc2cccc3cc(ncc23)-c2ccc(CN3CCN(C)CC3)cc2)c2c(N)ncnc12 Show InChI InChI=1S/C31H32N8/c1-21(2)39-31-29(30(32)34-20-35-31)27(36-39)12-11-23-5-4-6-25-17-28(33-18-26(23)25)24-9-7-22(8-10-24)19-38-15-13-37(3)14-16-38/h4-10,17-18,20-21H,13-16,19H2,1-3H3,(H2,32,34,35) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 211 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Southern California
Curated by ChEMBL
| Assay Description Inhibition of BCR-ABL (unknown origin) expressed in mouse BA/F3 cells assessed as reduction in ABL phosphorylation at Y412 residue incubated for 3 hr... |
Eur J Med Chem 146: 519-528 (2018)
Article DOI: 10.1016/j.ejmech.2018.01.053 BindingDB Entry DOI: 10.7270/Q23N261S |
More data for this Ligand-Target Pair | |
Serine/threonine-protein kinase B-raf
(Homo sapiens (Human)) | BDBM50462185
![PNG](/data/jpeg/tenK5046/BindingDB_50462185.png) (CHEMBL4237900)Show SMILES CC(C)n1nc(C#Cc2cccc3cc(ncc23)-c2ccc(CN3CCN(C)CC3)cc2)c2c(N)ncnc12 Show InChI InChI=1S/C31H32N8/c1-21(2)39-31-29(30(32)34-20-35-31)27(36-39)12-11-23-5-4-6-25-17-28(33-18-26(23)25)24-9-7-22(8-10-24)19-38-15-13-37(3)14-16-38/h4-10,17-18,20-21H,13-16,19H2,1-3H3,(H2,32,34,35) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Southern California
Curated by ChEMBL
| Assay Description Inhibition of BRAF V600E mutant in human A375 cells assessed as reduction in cell proliferation incubated for 96 hrs by MTT assay |
Eur J Med Chem 146: 519-528 (2018)
Article DOI: 10.1016/j.ejmech.2018.01.053 BindingDB Entry DOI: 10.7270/Q23N261S |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase ABL1
(Homo sapiens (Human)) | BDBM50462185
![PNG](/data/jpeg/tenK5046/BindingDB_50462185.png) (CHEMBL4237900)Show SMILES CC(C)n1nc(C#Cc2cccc3cc(ncc23)-c2ccc(CN3CCN(C)CC3)cc2)c2c(N)ncnc12 Show InChI InChI=1S/C31H32N8/c1-21(2)39-31-29(30(32)34-20-35-31)27(36-39)12-11-23-5-4-6-25-17-28(33-18-26(23)25)24-9-7-22(8-10-24)19-38-15-13-37(3)14-16-38/h4-10,17-18,20-21H,13-16,19H2,1-3H3,(H2,32,34,35) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 7 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Southern California
Curated by ChEMBL
| Assay Description Inhibition of ABL (unknown origin) by phosphocellulose paper disk assay |
Eur J Med Chem 146: 519-528 (2018)
Article DOI: 10.1016/j.ejmech.2018.01.053 BindingDB Entry DOI: 10.7270/Q23N261S |
More data for this Ligand-Target Pair | |
Serine/threonine-protein kinase B-raf
(Homo sapiens (Human)) | BDBM50462185
![PNG](/data/jpeg/tenK5046/BindingDB_50462185.png) (CHEMBL4237900)Show SMILES CC(C)n1nc(C#Cc2cccc3cc(ncc23)-c2ccc(CN3CCN(C)CC3)cc2)c2c(N)ncnc12 Show InChI InChI=1S/C31H32N8/c1-21(2)39-31-29(30(32)34-20-35-31)27(36-39)12-11-23-5-4-6-25-17-28(33-18-26(23)25)24-9-7-22(8-10-24)19-38-15-13-37(3)14-16-38/h4-10,17-18,20-21H,13-16,19H2,1-3H3,(H2,32,34,35) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 51 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Southern California
Curated by ChEMBL
| Assay Description Inhibition of BRAF V600E mutant (unknown origin) after 20 mins by immunoblotting assay |
Eur J Med Chem 146: 519-528 (2018)
Article DOI: 10.1016/j.ejmech.2018.01.053 BindingDB Entry DOI: 10.7270/Q23N261S |
More data for this Ligand-Target Pair | |
Breakpoint cluster region protein/Tyrosine-protein kinase ABL1
(Homo sapiens (Human)) | BDBM50462185
![PNG](/data/jpeg/tenK5046/BindingDB_50462185.png) (CHEMBL4237900)Show SMILES CC(C)n1nc(C#Cc2cccc3cc(ncc23)-c2ccc(CN3CCN(C)CC3)cc2)c2c(N)ncnc12 Show InChI InChI=1S/C31H32N8/c1-21(2)39-31-29(30(32)34-20-35-31)27(36-39)12-11-23-5-4-6-25-17-28(33-18-26(23)25)24-9-7-22(8-10-24)19-38-15-13-37(3)14-16-38/h4-10,17-18,20-21H,13-16,19H2,1-3H3,(H2,32,34,35) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 354 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Southern California
Curated by ChEMBL
| Assay Description Inhibition of BCR-ABL (unknown origin) expressed in mouse BA/F3 cells assessed as reduction in cell proliferation incubated for 48 hrs by MTT assay |
Eur J Med Chem 146: 519-528 (2018)
Article DOI: 10.1016/j.ejmech.2018.01.053 BindingDB Entry DOI: 10.7270/Q23N261S |
More data for this Ligand-Target Pair | |