Found 6 hits for monomerid = 50462238 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kcal/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Histone deacetylase
(Homo sapiens (Human)) | BDBM50462238
(CHEMBL4247905)Show SMILES CC(C)c1cc(C(=O)N2CCc3cc(NC(=O)CCCCCCCC(=O)NO)ccc23)c(O)cc1O Show InChI InChI=1S/C27H35N3O6/c1-17(2)20-15-21(24(32)16-23(20)31)27(35)30-13-12-18-14-19(10-11-22(18)30)28-25(33)8-6-4-3-5-7-9-26(34)29-36/h10-11,14-17,31-32,36H,3-9,12-13H2,1-2H3,(H,28,33)(H,29,34) | PDB
UniProtKB/SwissProt
UniProtKB/TrEMBL
antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 174 | n/a | n/a | n/a | n/a | n/a | n/a |
Taipei Medical University
Curated by ChEMBL
| Assay Description
Inhibition of HDAC in human HeLa nuclear extract using Ac-Lys(Ac)-pNA as substrate measured after 30 mins by fluorometric analysis |
Eur J Med Chem 150: 667-677 (2018)
Article DOI: 10.1016/j.ejmech.2018.03.006
BindingDB Entry DOI: 10.7270/Q2XW4NGM |
More data for this
Ligand-Target Pair | |
Heat shock protein HSP 90-alpha
(Homo sapiens (Human)) | BDBM50462238
(CHEMBL4247905)Show SMILES CC(C)c1cc(C(=O)N2CCc3cc(NC(=O)CCCCCCCC(=O)NO)ccc23)c(O)cc1O Show InChI InChI=1S/C27H35N3O6/c1-17(2)20-15-21(24(32)16-23(20)31)27(35)30-13-12-18-14-19(10-11-22(18)30)28-25(33)8-6-4-3-5-7-9-26(34)29-36/h10-11,14-17,31-32,36H,3-9,12-13H2,1-2H3,(H,28,33)(H,29,34) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
UniProtKB/TrEMBL
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 52 | n/a | n/a | n/a | n/a | n/a | n/a |
Taipei Medical University
Curated by ChEMBL
| Assay Description
Inhibition of FITC-geldanamycin binding to HSP90alpha (unknown origin) after 3 hrs by fluorescence polarization assay |
Eur J Med Chem 150: 667-677 (2018)
Article DOI: 10.1016/j.ejmech.2018.03.006
BindingDB Entry DOI: 10.7270/Q2XW4NGM |
More data for this
Ligand-Target Pair | |
Cereblon/Histone deacetylase 6
(Homo sapiens (Human)) | BDBM50462238
(CHEMBL4247905)Show SMILES CC(C)c1cc(C(=O)N2CCc3cc(NC(=O)CCCCCCCC(=O)NO)ccc23)c(O)cc1O Show InChI InChI=1S/C27H35N3O6/c1-17(2)20-15-21(24(32)16-23(20)31)27(35)30-13-12-18-14-19(10-11-22(18)30)28-25(33)8-6-4-3-5-7-9-26(34)29-36/h10-11,14-17,31-32,36H,3-9,12-13H2,1-2H3,(H,28,33)(H,29,34) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
UniProtKB/TrEMBL
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 9.25E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Taipei Medical University
Curated by ChEMBL
| Assay Description
Inhibition of human HDAC6 using RHKK(Ac) as substrate |
Eur J Med Chem 150: 667-677 (2018)
Article DOI: 10.1016/j.ejmech.2018.03.006
BindingDB Entry DOI: 10.7270/Q2XW4NGM |
More data for this
Ligand-Target Pair | |
Histone deacetylase 3
(Homo sapiens (Human)) | BDBM50462238
(CHEMBL4247905)Show SMILES CC(C)c1cc(C(=O)N2CCc3cc(NC(=O)CCCCCCCC(=O)NO)ccc23)c(O)cc1O Show InChI InChI=1S/C27H35N3O6/c1-17(2)20-15-21(24(32)16-23(20)31)27(35)30-13-12-18-14-19(10-11-22(18)30)28-25(33)8-6-4-3-5-7-9-26(34)29-36/h10-11,14-17,31-32,36H,3-9,12-13H2,1-2H3,(H,28,33)(H,29,34) | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.81E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Taipei Medical University
Curated by ChEMBL
| Assay Description
Inhibition of human HDAC3 using RHKK(Ac) as substrate |
Eur J Med Chem 150: 667-677 (2018)
Article DOI: 10.1016/j.ejmech.2018.03.006
BindingDB Entry DOI: 10.7270/Q2XW4NGM |
More data for this
Ligand-Target Pair | |
Histone deacetylase 8
(Homo sapiens (Human)) | BDBM50462238
(CHEMBL4247905)Show SMILES CC(C)c1cc(C(=O)N2CCc3cc(NC(=O)CCCCCCCC(=O)NO)ccc23)c(O)cc1O Show InChI InChI=1S/C27H35N3O6/c1-17(2)20-15-21(24(32)16-23(20)31)27(35)30-13-12-18-14-19(10-11-22(18)30)28-25(33)8-6-4-3-5-7-9-26(34)29-36/h10-11,14-17,31-32,36H,3-9,12-13H2,1-2H3,(H,28,33)(H,29,34) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.22E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Taipei Medical University
Curated by ChEMBL
| Assay Description
Inhibition of human HDAC8 using RHKAcKAc as substrate |
Eur J Med Chem 150: 667-677 (2018)
Article DOI: 10.1016/j.ejmech.2018.03.006
BindingDB Entry DOI: 10.7270/Q2XW4NGM |
More data for this
Ligand-Target Pair | |
Cereblon/Histone deacetylase 1
(Homo sapiens (Human)) | BDBM50462238
(CHEMBL4247905)Show SMILES CC(C)c1cc(C(=O)N2CCc3cc(NC(=O)CCCCCCCC(=O)NO)ccc23)c(O)cc1O Show InChI InChI=1S/C27H35N3O6/c1-17(2)20-15-21(24(32)16-23(20)31)27(35)30-13-12-18-14-19(10-11-22(18)30)28-25(33)8-6-4-3-5-7-9-26(34)29-36/h10-11,14-17,31-32,36H,3-9,12-13H2,1-2H3,(H,28,33)(H,29,34) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
UniProtKB/TrEMBL
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.95E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Taipei Medical University
Curated by ChEMBL
| Assay Description
Inhibition of human HDAC1 using RHKK(Ac) as substrate |
Eur J Med Chem 150: 667-677 (2018)
Article DOI: 10.1016/j.ejmech.2018.03.006
BindingDB Entry DOI: 10.7270/Q2XW4NGM |
More data for this
Ligand-Target Pair | |
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