BDBM50462746 CHEMBL4239430

SMILES: Cn1nc(C2CC2)c2ccc(Nc3n[nH]c4cccnc34)cc12

InChI Key: InChIKey=KFHLKGASZJEOJF-UHFFFAOYSA-N

Data: 1 IC50  2 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50462746   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Metabotropic glutamate receptor 4 (Homo sapiens (Human))	BDBM50462746 (CHEMBL4239430) Show SMILES Cn1nc(C2CC2)c2ccc(Nc3n[nH]c4cccnc34)cc12 Show InChI InChI=1S/C17H16N6/c1-23-14-9-11(6-7-12(14)15(22-23)10-4-5-10)19-17-16-13(20-21-17)3-2-8-18-16/h2-3,6-10H,4-5H2,1H3,(H2,19,20,21)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	43	n/a	n/a	n/a	n/a
Vanderbilt University Curated by ChEMBL					Assay Description Positive allosteric modulation of human mGluR4 expressed in CHO cells co-expressing Gqi5 assessed as increase in glutamate-induced calcium flux prein...				Bioorg Med Chem Lett 28: 2641-2646 (2018) Article DOI: 10.1016/j.bmcl.2018.06.034 BindingDB Entry DOI: 10.7270/Q2DR2Z5H
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 4 (Homo sapiens (Human))	BDBM50462746 (CHEMBL4239430) Show SMILES Cn1nc(C2CC2)c2ccc(Nc3n[nH]c4cccnc34)cc12 Show InChI InChI=1S/C17H16N6/c1-23-14-9-11(6-7-12(14)15(22-23)10-4-5-10)19-17-16-13(20-21-17)3-2-8-18-16/h2-3,6-10H,4-5H2,1H3,(H2,19,20,21)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	43	n/a	n/a	n/a	n/a
Vanderbilt University Curated by ChEMBL					Assay Description Positive allosteric modulation of human mGlu4 receptor expressed in CHO cells co-expressing Gqi5 assessed as increase in glutamate-induced calcium mo...				J Med Chem 62: 342-358 (2019) Article DOI: 10.1021/acs.jmedchem.8b00994
					More data for this Ligand-Target Pair
Cytochrome P450 1A (Homo sapiens (Human))	BDBM50462746 (CHEMBL4239430) Show SMILES Cn1nc(C2CC2)c2ccc(Nc3n[nH]c4cccnc34)cc12 Show InChI InChI=1S/C17H16N6/c1-23-14-9-11(6-7-12(14)15(22-23)10-4-5-10)19-17-16-13(20-21-17)3-2-8-18-16/h2-3,6-10H,4-5H2,1H3,(H2,19,20,21)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	350	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Curated by ChEMBL					Assay Description Inhibition of CYP1A2 in human liver microsomes				Bioorg Med Chem Lett 28: 2641-2646 (2018) Article DOI: 10.1016/j.bmcl.2018.06.034 BindingDB Entry DOI: 10.7270/Q2DR2Z5H
					More data for this Ligand-Target Pair