BDBM50462747 CHEMBL4245763::US10508105, Compound 1

SMILES: CC(C)Oc1nn(C)c2cc(Nc3n[nH]c4cccnc34)ccc12

InChI Key: InChIKey=KUOLUIXWHMAUNN-UHFFFAOYSA-N

Data: 2 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50462747   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Metabotropic glutamate receptor 4 (Homo sapiens (Human))	BDBM50462747 (CHEMBL4245763 | US10508105, Compound 1) Show SMILES CC(C)Oc1nn(C)c2cc(Nc3n[nH]c4cccnc34)ccc12 Show InChI InChI=1S/C17H18N6O/c1-10(2)24-17-12-7-6-11(9-14(12)23(3)22-17)19-16-15-13(20-21-16)5-4-8-18-15/h4-10H,1-3H3,(H2,19,20,21)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	413	n/a	n/a	n/a	n/a
Vanderbilt University US Patent					Assay Description The disclosed compounds and compositions can be evaluated for their ability to act as a potentiatior of metabotropic glutamate receptor activity, in ...				US Patent US10508105 (2019) BindingDB Entry DOI: 10.7270/Q2WH2SC2
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 4 (Homo sapiens (Human))	BDBM50462747 (CHEMBL4245763 | US10508105, Compound 1) Show SMILES CC(C)Oc1nn(C)c2cc(Nc3n[nH]c4cccnc34)ccc12 Show InChI InChI=1S/C17H18N6O/c1-10(2)24-17-12-7-6-11(9-14(12)23(3)22-17)19-16-15-13(20-21-16)5-4-8-18-15/h4-10H,1-3H3,(H2,19,20,21)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	413	n/a	n/a	n/a	n/a
Vanderbilt University Curated by ChEMBL					Assay Description Positive allosteric modulation of human mGluR4 expressed in CHO cells co-expressing Gqi5 assessed as increase in glutamate-induced calcium flux prein...				Bioorg Med Chem Lett 28: 2641-2646 (2018) Article DOI: 10.1016/j.bmcl.2018.06.034 BindingDB Entry DOI: 10.7270/Q2DR2Z5H
					More data for this Ligand-Target Pair