BDBM50462757 CHEMBL4249226

SMILES: Cn1nc(C(=O)NC2CCC2)c2ccc(Nc3n[nH]c4cccnc34)cc12

InChI Key: InChIKey=WFBBBHNOOAQNAB-UHFFFAOYSA-N

Data: 1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50462757   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Metabotropic glutamate receptor 4 (Homo sapiens (Human))	BDBM50462757 (CHEMBL4249226) Show SMILES Cn1nc(C(=O)NC2CCC2)c2ccc(Nc3n[nH]c4cccnc34)cc12 Show InChI InChI=1S/C19H19N7O/c1-26-15-10-12(21-18-17-14(23-24-18)6-3-9-20-17)7-8-13(15)16(25-26)19(27)22-11-4-2-5-11/h3,6-11H,2,4-5H2,1H3,(H,22,27)(H2,21,23,24)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	653	n/a	n/a	n/a	n/a
Vanderbilt University Curated by ChEMBL					Assay Description Positive allosteric modulation of human mGluR4 expressed in CHO cells co-expressing Gqi5 assessed as increase in glutamate-induced calcium flux prein...				Bioorg Med Chem Lett 28: 2641-2646 (2018) Article DOI: 10.1016/j.bmcl.2018.06.034 BindingDB Entry DOI: 10.7270/Q2DR2Z5H
					More data for this Ligand-Target Pair